Journal article
Brain Mineralocorticoid Receptor Control of Blood Pressure and Kidney Function in Normotensive Rats
Hypertension (Dallas, Tex. 1979), Vol.33(5), pp.1201-1206
05/1999
DOI: 10.1161/01.HYP.33.5.1201
PMID: 10334812
Abstract
Brain mineralocorticoid receptors appear to contribute to mineralocorticoid hypertension and may be involved in blood pressure control in normotensive rats. We examined the effect of blockade of central mineralocorticoid receptors with the use of a selective antagonist (RU28318) on cardiovascular and renal function in conscious normotensive rats. The contribution of renal innervation was evaluated in rats with bilaterally denervated kidneys. Young adult, male Wistar rats were trained for systolic blood pressure measurement by a tail sphygmographic method and accustomed to metabolic cages for collection of urine. One week before experimentation, an intracerebroventricular cannula was implanted. Systolic blood pressure was diminished 30 minutes after an intracerebroventricular dose of 10 ng of RU28318. The effect was maximal at 8 hours and was still present after 24 hours. Blood pressure returned to the basal level by 48 hours. During the period 0 to 8 hours after intracerebroventricular injection, rats treated with the antagonist showed an increase in diuresis and urinary electrolyte excretion. No significant effect on plasma renin activity, measured 8 and 30 hours after administration of RU28318, was observed. In denervated rats, the decrease in systolic blood pressure after administration of RU28318 was reduced. The difference was statistically significant compared with controls at 2 hours but not at 8 hours, and blood pressure returned to the basal value by 24 hours. The increases in diuresis and urinary electrolyte excretion induced by RU28318 were abolished in denervated rats. These results show that brain mineralocorticoid receptors are involved in blood pressure regulation and kidney function homeostasis in conscious normotensive rats. The renal nerves appear to participate in the brain mineralocorticoid receptor control of blood pressure.
Details
- Title: Subtitle
- Brain Mineralocorticoid Receptor Control of Blood Pressure and Kidney Function in Normotensive Rats
- Creators
- Kamal Rahmouni - From the Institut de Pharmacologie (K.R., M.B., M.G., J.-L.I., W.D.J.) and Laboratoire de Pharmacologie-Physiologie Rénovasculaire, Faculté de Médecine, Université Louis Pasteur (K.R., M.B., M.G., J.-L.I.), and Service d’Hypertension artérielle, Maladies vasculaires et Pharmacologie clinique, Hôpitaux Universitaires de Strasbourg (J.-L.I.), Strasbourg, FranceMariette Barthelmebs - From the Institut de Pharmacologie (K.R., M.B., M.G., J.-L.I., W.D.J.) and Laboratoire de Pharmacologie-Physiologie Rénovasculaire, Faculté de Médecine, Université Louis Pasteur (K.R., M.B., M.G., J.-L.I.), and Service d’Hypertension artérielle, Maladies vasculaires et Pharmacologie clinique, Hôpitaux Universitaires de Strasbourg (J.-L.I.), Strasbourg, FranceMichèle Grima - From the Institut de Pharmacologie (K.R., M.B., M.G., J.-L.I., W.D.J.) and Laboratoire de Pharmacologie-Physiologie Rénovasculaire, Faculté de Médecine, Université Louis Pasteur (K.R., M.B., M.G., J.-L.I.), and Service d’Hypertension artérielle, Maladies vasculaires et Pharmacologie clinique, Hôpitaux Universitaires de Strasbourg (J.-L.I.), Strasbourg, FranceJean-Louis Imbs - From the Institut de Pharmacologie (K.R., M.B., M.G., J.-L.I., W.D.J.) and Laboratoire de Pharmacologie-Physiologie Rénovasculaire, Faculté de Médecine, Université Louis Pasteur (K.R., M.B., M.G., J.-L.I.), and Service d’Hypertension artérielle, Maladies vasculaires et Pharmacologie clinique, Hôpitaux Universitaires de Strasbourg (J.-L.I.), Strasbourg, FranceWybren De Jong - From the Institut de Pharmacologie (K.R., M.B., M.G., J.-L.I., W.D.J.) and Laboratoire de Pharmacologie-Physiologie Rénovasculaire, Faculté de Médecine, Université Louis Pasteur (K.R., M.B., M.G., J.-L.I.), and Service d’Hypertension artérielle, Maladies vasculaires et Pharmacologie clinique, Hôpitaux Universitaires de Strasbourg (J.-L.I.), Strasbourg, France
- Resource Type
- Journal article
- Publication Details
- Hypertension (Dallas, Tex. 1979), Vol.33(5), pp.1201-1206
- DOI
- 10.1161/01.HYP.33.5.1201
- PMID
- 10334812
- ISSN
- 0194-911X
- eISSN
- 1524-4563
- Language
- English
- Date published
- 05/1999
- Academic Unit
- Iowa Neuroscience Institute; Neuroscience and Pharmacology; Internal Medicine
- Record Identifier
- 9984040366802771
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