Brain-Performance Correlates of Working Memory Retrieval in Schizophrenia: A Cognitive Modeling Approach

Gregory G Brown; Gregory McCarthy; Amanda Bischoff-Grethe; Burak Ozyurt; Doug Greve; Steven G Potkin; Jessica A Turner; Randy Notestine; Vince D Calhoun; Judy M Ford; Daniel Mathalon; Dara S Manoach; Syam Gadde; Gary H Glover; Cynthia G Wible; Aysenil Belger; Randy L Gollub; John Lauriello; Daniel O'Leary; Kelvin O Lim

doi:10.1093/schbul/sbn149

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Brain-Performance Correlates of Working Memory Retrieval in Schizophrenia: A Cognitive Modeling Approach

Journal article

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Brain-Performance Correlates of Working Memory Retrieval in Schizophrenia: A Cognitive Modeling Approach

Gregory G Brown, Gregory McCarthy, Amanda Bischoff-Grethe, Burak Ozyurt, Doug Greve, Steven G Potkin, Jessica A Turner, Randy Notestine, Vince D Calhoun, Judy M Ford, …

Schizophrenia bulletin, Vol.35(1), pp.32-46

01/2009

DOI: 10.1093/schbul/sbn149

PMCID: PMC2643949

PMID: 19023127

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https://pmc.ncbi.nlm.nih.gov/articles/PMC2643949/View

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Abstract

Correlations of cognitive functioning with brain activation during a sternberg item recognition paradigm (SIRP) were investigated in patients with schizophrenia and in healthy controls studied at 8 sites. To measure memory scanning times, 4 response time models were fit to SIRP data. The best fitting model assumed exhaustive serial memory scanning followed by self-terminating memory search and involved one intercept parameter to represent SIRP processes not contributing directly to memory scanning. Patients displayed significantly longer response times with increasing memory load and differed on the memory scanning, memory search, and intercept parameters of the best fitting probability model. Groups differed in the correlation between the memory scanning parameter and linear brain response to increasing memory load within left inferior and left middle frontal gyrus, bilateral caudate, and right precuneus. The pattern of findings in these regions indicated that high scanning capacity was associated with high neural capacity among healthy subjects but that scanning speed was uncoupled from brain response to increasing memory load among schizophrenia patients. Group differences in correlation of the best fitting model's scanning parameter with a quadratic trend in brain response to increasing memory load suggested inefficient or disordered patterns of neural inhibition among individuals with schizophrenia, especially in the left perirhinal and entorhinal cortices. The results show at both cognitive and neural levels that disordered memory scanning contributes to deficient SIRP performance among schizophrenia patients.

Stochastic Models

Schizophrenia

item recognition

The FBIRN Imaging Consortium Guest Editors

Theme

Steven Potkin and Judith Ford

functional magnetic resonance imaging

Wide Spread Cortical Dysfunction in Schizophrenia

Details

Title: Subtitle: Brain-Performance Correlates of Working Memory Retrieval in Schizophrenia: A Cognitive Modeling Approach
Creators: Gregory G Brown - Department of Psychiatry; Minneapolis VA Medical Center, University of Minnesota
Gregory McCarthy - Department of Psychiatry; Minneapolis VA Medical Center, University of Minnesota
Amanda Bischoff-Grethe - Department of Psychiatry; Minneapolis VA Medical Center, University of Minnesota
Burak Ozyurt - Department of Psychiatry; Minneapolis VA Medical Center, University of Minnesota
Doug Greve - Department of Psychiatry; Minneapolis VA Medical Center, University of Minnesota
Steven G Potkin - Department of Psychiatry; Minneapolis VA Medical Center, University of Minnesota
Jessica A Turner - Department of Psychiatry; Minneapolis VA Medical Center, University of Minnesota
Randy Notestine - Department of Psychiatry; Minneapolis VA Medical Center, University of Minnesota
Vince D Calhoun - Department of Psychiatry; Minneapolis VA Medical Center, University of Minnesota
Judy M Ford - Department of Psychiatry; Minneapolis VA Medical Center, University of Minnesota
Daniel Mathalon - Department of Psychiatry; Minneapolis VA Medical Center, University of Minnesota
Dara S Manoach - Department of Psychiatry; Minneapolis VA Medical Center, University of Minnesota
Syam Gadde - Department of Psychiatry; Minneapolis VA Medical Center, University of Minnesota
Gary H Glover - Department of Psychiatry; Minneapolis VA Medical Center, University of Minnesota
Cynthia G Wible - Department of Psychiatry; Minneapolis VA Medical Center, University of Minnesota
Aysenil Belger - Department of Psychiatry; Minneapolis VA Medical Center, University of Minnesota
Randy L Gollub - Department of Psychiatry; Minneapolis VA Medical Center, University of Minnesota
John Lauriello - Department of Psychiatry; Minneapolis VA Medical Center, University of Minnesota
Daniel O'Leary - Department of Psychiatry; Minneapolis VA Medical Center, University of Minnesota
Kelvin O Lim - Department of Psychiatry; Minneapolis VA Medical Center, University of Minnesota
Resource Type: Journal article
Publication Details: Schizophrenia bulletin, Vol.35(1), pp.32-46
DOI: 10.1093/schbul/sbn149
PMID: 19023127
PMCID: PMC2643949
NLM abbreviation: Schizophr Bull
ISSN: 0586-7614
eISSN: 1745-1701
Publisher: Oxford University Press
Language: English
Date published: 01/2009
Academic Unit: Psychiatry
Record Identifier: 9984003995302771

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