Journal article
Brain Tumors Occurring before 1 Year of Age: A Retrospective Review of 22 Cases in an 11-Year Period (1977-1987)
Neurosurgery, Vol.29(1), pp.8-13
07/01/1991
DOI: 10.1227/00006123-199107000-00002
PMID: 1651461
Abstract
Abstract Congenital brain tumors have been reported infrequently and their management remains ill defined. An 11-year review (1977-1987) of all children with brain tumors with the onset of symptoms before 1 year of age was completed. Twenty-two children with the following histological diagnoses were treated: astrocytoma (7 patients), primitive neuroectodermal tumor (6 patients), papilloma or carcinoma of the choroid plexus (3 patients), malignant teratoma (2 patients), dermoid tumor (2 patients), embryonal rhabdomyosarcoma (1 patient), and chloroma (1 patient). Fifteen tumors were supratentorial in location, and 7 were infratentorial. Initial symptoms were hydrocephalus (32%), focal neurological deficit (23%), asymptomatic increase in head circumference (18%), failure to thrive (14%), and seizures (4.5%). The goal of treatment was a radical excision when possible, with primary chemotherapy in the last 6 years of the review period. Radiation therapy was the adjunct to surgery in the initial 5-year period. All patients with papillomas of the choroid plexus and dermoid lesions underwent a total resection with no recurrence. All 7 astrocytomas were supratentorial, with 6 occurring in the diencephalon. Five of the seven patients with astrocytomas survived more than 5 years. The 6 primitive neuroectodermal tumors were located equally between the supra- and infratentorial spaces. Four of the 6 infants with these tumors received chemotherapy (2 received chemotherapy alone; 2 received chemotherapy and radiation therapy) and are tumor free 2 to 9 years later. A fifth child received radiation therapy alone early in the series and survived only 4 months. The family of the other child refused adjunctive treatment. A radical resection with chemotherapy appears to be the rational approach, keeping additional operations and radiation therapy as options for recurrent disease while avoiding the effects of irradiation on the developing brain.
Details
- Title: Subtitle
- Brain Tumors Occurring before 1 Year of Age: A Retrospective Review of 22 Cases in an 11-Year Period (1977-1987)
- Creators
- Souheil F Haddad - Divisions of Neurosurgery, The University of Iowa College of Medicine, Iowa City, IowaArnold H Menezes - Divisions of Neurosurgery, The University of Iowa College of Medicine, Iowa City, IowaWilliam E Bell - Divisions of Pediatric Neurology, The University of Iowa College of Medicine, Iowa City, IowaJohn C Godersky - Divisions of Neurosurgery, The University of Iowa College of Medicine, Iowa City, Iowa, Anchorage Neurosurgical Associates. 2841 DeBarr Road, Suite 34, Anchorage, AK 99508Adel K Afifi - Divisions of Pediatric Neurology, The University of Iowa College of Medicine, Iowa City, IowaJames F Bale - Divisions of Pediatric Neurology, The University of Iowa College of Medicine, Iowa City, Iowa
- Resource Type
- Journal article
- Publication Details
- Neurosurgery, Vol.29(1), pp.8-13
- DOI
- 10.1227/00006123-199107000-00002
- PMID
- 1651461
- ISSN
- 0148-396X
- eISSN
- 1524-4040
- Language
- English
- Date published
- 07/01/1991
- Academic Unit
- Neurology; Stead Family Department of Pediatrics; Neurosurgery; Otolaryngology
- Record Identifier
- 9984040490602771
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