Journal article
Brain activation during dual-task processing is associated with cardiorespiratory fitness and performance in older adults
Frontiers in aging neuroscience, Vol.7, pp.154-154
08/12/2015
DOI: 10.3389/fnagi.2015.00154
PMCID: PMC4532928
PMID: 26321949
Abstract
Higher cardiorespiratory fitness is associated with better cognitive performance and enhanced brain activation. Yet, the extent to which cardiorespiratory fitness-related brain activation is associated with better cognitive performance is not well understood. In this cross-sectional study, we examined whether the association between cardiorespiratory fitness and executive function was mediated by greater prefrontal cortex activation in healthy older adults. Brain activation was measured during dual-task performance with functional magnetic resonance imaging in a sample of 128 healthy older adults (59–80 years). Higher cardiorespiratory fitness was associated with greater activation during dual-task processing in several brain areas including the anterior cingulate and supplementary motor cortex (ACC/SMA), thalamus and basal ganglia, right motor/somatosensory cortex and middle frontal gyrus, and left somatosensory cortex, controlling for age, sex, education, and gray matter volume. Of these regions, greater ACC/SMA activation mediated the association between cardiorespiratory fitness and dual-task performance. We provide novel evidence that cardiorespiratory fitness may support cognitive performance by facilitating brain activation in a core region critical for executive function.
Details
- Title: Subtitle
- Brain activation during dual-task processing is associated with cardiorespiratory fitness and performance in older adults
- Creators
- Chelsea N Wong - The Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-ChampaignLaura Chaddock-Heyman - The Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-ChampaignMichelle W Voss - Department of Psychology, University of IowaAgnieszka Z Burzynska - The Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-ChampaignChandramallika Basak - The Center for Vital Longevity, School of Behavioral and Brain Sciences, University of Texas at DallasKirk I Erickson - Department of Psychology, University of PittsburghRuchika S Prakash - Department of Psychology, The Ohio State UniversityAmanda N Szabo-Reed - Cardiovascular Research Institute, University of Kansas Medical CenterSiobhan M Phillips - Department of Preventative Medicine, Northwestern University Medical SchoolThomas Wojcicki - Exercise Science, Lansing School of Nursing and Health Sciences, Bellarmine UniversityEmily L Mailey - Department of Kinesiology, Kansas State UniversityEdward McAuley - Department of Kinesiology and Community Health, University of Illinois at Urbana-ChampaignArthur F Kramer - The Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign
- Resource Type
- Journal article
- Publication Details
- Frontiers in aging neuroscience, Vol.7, pp.154-154
- DOI
- 10.3389/fnagi.2015.00154
- PMID
- 26321949
- PMCID
- PMC4532928
- NLM abbreviation
- Front Aging Neurosci
- ISSN
- 1663-4365
- eISSN
- 1663-4365
- Publisher
- Frontiers Media S.A
- Language
- English
- Date published
- 08/12/2015
- Academic Unit
- Psychological and Brain Sciences; Iowa Neuroscience Institute
- Record Identifier
- 9984002478402771
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