Journal article
Brain-based classification of youth with anxiety disorders: transdiagnostic examinations within the ENIGMA-Anxiety database using machine learning
Nature mental health, Vol.2(1), pp.104-118
01/01/2024
DOI: 10.1038/s44220-023-00173-2
Abstract
Neuroanatomical findings on youth anxiety disorders are notoriously difficult to replicate, small in effect size and have limited clinical relevance. These concerns have prompted a paradigm shift toward highly powered (that is, big data) individual-level inferences, which are data driven, transdiagnostic and neurobiologically informed. Here we built and validated supervised neuroanatomical machine learning models for individual-level inferences, using a case-control design and the largest known neuroimaging database on youth anxiety disorders: the ENIGMA-Anxiety Consortium (N = 3,343; age = 10-25 years; global sites = 32). Modest, yet robust, brain-based classifications were achieved for specific anxiety disorders (panic disorder), but also transdiagnostically for all anxiety disorders when patients were subgrouped according to their sex, medication status and symptom severity (area under the receiver operating characteristic curve, 0.59-0.63). Classifications were driven by neuroanatomical features (cortical thickness, cortical surface area and subcortical volumes) in fronto-striato-limbic and temporoparietal regions. This benchmark study within a large, heterogeneous and multisite sample of youth with anxiety disorders reveals that only modest classification performances can be realistically achieved with machine learning using neuroanatomical data.
Details
- Title: Subtitle
- Brain-based classification of youth with anxiety disorders: transdiagnostic examinations within the ENIGMA-Anxiety database using machine learning
- Creators
- Willem B. Bruin - Leiden UniversityPaul Zhutovsky - Amsterdam NeuroscienceGuido A. van Wingen - Amsterdam NeuroscienceJanna Marie Bas-Hoogendam - Leiden UniversityNynke A. Groenewold - University of Cape TownKevin Hilbert - University of ErfurtAnderson M. Winkler - The University of Texas Rio Grande ValleyAndre Zugman - National Institute of Mental HealthFederica Agosta - Vita-Salute San Raffaele UniversityFredrik Ahs - Mid Sweden UniversityCarmen Andreescu - University of PittsburghChase Antonacci - Palo Alto UniversityTakeshi Asami - Yokohama City UniversityMichal Assaf - Yale UniversityJacques P. Barber - Adelphi UniversityJochen Bauer - University of MünsterShreya Y. Bavdekar - University of RochesterKatja Beesdo-Baum - Technische Universität DresdenFrancesco Benedetti - Vita-Salute San Raffaele UniversityRachel Bernstein - National Institute of Mental HealthJohannes Bjorkstrand - Lund UniversityRobert J. Blair - University of CopenhagenKarina S. Blair - Boys TownLaura Blanco-Hinojo - Instituto de Salud Carlos IIIJoscha Bohnlein - University of MünsterPaolo Brambilla - University of MilanRodrigo A. Bressan - Universidade Federal de São PauloFabian Breuer - University of MünsterMarta Cano - Instituto de Salud Carlos IIIElisa Canu - Vita-Salute San Raffaele UniversityElise M. Cardinale - Catholic University of AmericaNarcis Cardoner - Universitat Autònoma de BarcelonaCamilla Cividini - Vita-Salute San Raffaele UniversityHenk Cremers - University of AmsterdamUdo Dannlowski - University of MünsterGretchen J. Diefenbach - Hartford HospitalKatharina Domschke - University of FreiburgAlexander G. G. Doruyter - Stellenbosch UniversityThomas Dresler - University of TübingenAngelika Erhardt - Max Planck Institute of PsychiatryMassimo Filippi - Vita-Salute San Raffaele UniversityGregory A. Fonzo - The University of Texas at AustinGabrielle F. Freitag - Florida Department of Children and FamiliesTomas Furmark - Uppsala UniversityTian Ge - Massachusetts General HospitalAndrew J. Gerber - Columbia University Irving Medical CenterSavannah N. Gosnell - Baylor College of MedicineHans J. Grabe - Universitätsmedizin GreifswaldDominik Grotegerd - University of MünsterRuben C. Gur - University of PennsylvaniaRaquel E. Gur - University of PennsylvaniaAlfons O. Hamm - Universität GreifswaldLaura K. M. Han - The University of MelbourneJennifer C. Harper - Washington University in St. LouisAnita Harrewijn - National Institute of Mental HealthAlexandre Heeren - UCLouvainDavid Hofmann - University of MünsterAndrea P. Jackowski - Østfold University of Applied SciencesNeda Jahanshad - University of Southern CaliforniaLaura Jett - National Institute of Mental HealthAntonia N. Kaczkurkin - Vanderbilt UniversityParmis Khosravi - National Institute of Mental HealthEllen N. Kingsley - Leeds and York Partnership NHS Foundation TrustTilo Kircher - Philipps University of MarburgMilutin Kostic - University of BelgradeBart Larsen - University of PennsylvaniaSang-Hyuk Lee - CHA UniversityElisabeth J. Leehr - University of MünsterEllen Leibenluft - National Institute of Mental HealthChristine Lochner - Stellenbosch UniversitySu Lui - Sichuan UniversityEleonora Maggioni - Fondazione IRCCS Ca' Granda Ospedale Maggiore PoliclinicoGisele G. Manfro - Universidade Federal do Rio Grande do SulKristoffer N. T. Mansson - Karolinska InstitutetClaire E. Marino - University of RochesterFrances Meeten - University of SussexBarbara Milrod - Albert Einstein College of MedicineAna Munjiza Jovanovic - Inst Mental Hlth, Belgrade, SerbiaBenson Mwangi - The University of Texas Health Science Center at HoustonMichael J. Myers - Washington University in St. LouisSusanne Neufang - Heinrich Heine University DüsseldorfJared A. Nielsen - Brigham Young UniversityPatricia A. Ohrmann - University of MünsterCristina Ottaviani - Fondazione Santa LuciaMartin P. Paulus - Laureate Institute for Brain ResearchMichael T. Perino - Washington University in St. LouisK. Luan Phan - The Ohio State UniversitySara Poletti - Vita-Salute San Raffaele UniversityDaniel Porta-Casteras - Universitat Autònoma de BarcelonaJesus Pujol - Instituto de Salud Carlos IIIAndrea Reinecke - Oxford Health NHS Foundation TrustGrace Ringlein - National Institute of Mental HealthPavel Rjabtsenkov - University of RochesterKarin Roelofs - Radboud University NijmegenRamiro Salas - Michael E. DeBakey VA Medical CenterGiovanni A. Salum - Universidade Federal do Rio Grande do SulTheodore D. Satterthwaite - University of PennsylvaniaElisabeth Schrammen - University of MünsterLisa Sindermann - University of BonnJordan W. Smoller - Massachusetts General HospitalJair C. Soares - The University of Texas Health Science Center at HoustonRudolf Stark - Justus-Liebig-Universität GießenFrederike Stein - Philipps University of MarburgThomas Straube - University of MünsterBenjamin Straube - Philipps University of MarburgJeffrey R. Strawn - Cincinnati Children's Hospital Medical CenterBenjamin Suarez-Jimenez - University of RochesterChad M. Sylvester - Washington University in St. LouisArdesheer Talati - Columbia University Irving Medical CenterSophia I. Thomopoulos - University of Southern CaliforniaRasit Tukel - Istanbul UniversityHelena van Nieuwenhuizen - Stony Brook UniversityKathryn Werwath - National Institute of Mental HealthKatharina Wittfeld - Universitätsmedizin GreifswaldBarry Wright - Leeds and York Partnership NHS Foundation TrustMon-Ju Wu - The University of Texas Health Science Center at HoustonYunbo Yang - Philipps University of MarburgAnna Zilverstand - University of MinnesotaPeter Zwanzger - LMU KlinikumJennifer U. Blackford - University of Nebraska Medical CenterSuzanne N. Avery - Vanderbilt University Medical CenterJacqueline A. Clauss - Harvard UniversityUlrike Lueken - Humboldt-Universität zu BerlinPaul M. Thompson - University of Southern CaliforniaDaniel S. Pine - National Institute of Mental HealthDan J. Stein - University of Cape TownNic J. A. van der Wee - Leiden University Medical CenterDick J. Veltman - Amsterdam University Medical CentersMoji Aghajani - Leiden UniversityInstitutionen för psykologi
- Resource Type
- Journal article
- Publication Details
- Nature mental health, Vol.2(1), pp.104-118
- DOI
- 10.1038/s44220-023-00173-2
- ISSN
- 2731-6076
- eISSN
- 2731-6076
- Publisher
- Springer Nature
- Number of pages
- 18
- Language
- English
- Date published
- 01/01/2024
- Academic Unit
- Psychiatry
- Record Identifier
- 9985223622302771
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