Journal article
Brain cancer stem cells: resilience through adaptive plasticity and hierarchical heterogeneity
Nature reviews. Cancer, Vol.22(9), pp.497-514
09/01/2022
DOI: 10.1038/s41568-022-00486-x
PMID: 35710946
Abstract
This Review discusses molecular circuitry underlying adaptive plasticity in brain cancer stem cells, highlighting the transcriptional classification of the stem cell state, neoplastic evolution and development of therapeutic resilience, and critical brain-specific microenvironmental inputs with the goal of informing next-generation stem-targeted treatment paradigms.
Malignant brain tumours are complex ecosystems containing neoplastic and stromal components that generate adaptive and evolutionarily driven aberrant tissues in the central nervous system. Brain cancers are cultivated by a dynamic population of stem-like cells that enforce intratumoural heterogeneity and respond to intrinsic microenvironment or therapeutically guided insults through proliferation, plasticity and restructuring of neoplastic and stromal components. Far from a rigid hierarchy, heterogeneous neoplastic populations transition between cellular states with differential self-renewal capacities, endowing them with powerful resilience. Here we review the biological machinery used by brain tumour stem cells to commandeer tissues in the intracranial space, evade immune responses and resist chemoradiotherapy. Through recent advances in single-cell sequencing, improved models to investigate the role of the tumour microenvironment and a deeper understanding of the fundamental role of the immune system in cancer biology, we are now better equipped to explore mechanisms by which these processes can be exploited for therapeutic benefit.
Details
- Title: Subtitle
- Brain cancer stem cells: resilience through adaptive plasticity and hierarchical heterogeneity
- Creators
- Ryan C. Gimple - Case Western Reserve UniversityKailin Yang - Cleveland ClinicMatthew E. Halbert - University of PittsburghSameer Agnihotri - University of PittsburghJeremy N. Rich - UPMC Hillman Cancer Center
- Resource Type
- Journal article
- Publication Details
- Nature reviews. Cancer, Vol.22(9), pp.497-514
- Publisher
- NATURE PORTFOLIO
- DOI
- 10.1038/s41568-022-00486-x
- PMID
- 35710946
- ISSN
- 1474-175X
- eISSN
- 1474-1768
- Number of pages
- 18
- Grant note
- Conquer Cancer, the ASCO Foundation Joshua's Wish Foundation T32CA094186 / Computational Genomic Epidemiology of Cancer program at Case Comprehensive Cancer Center F30CA217065 / US National Institutes of Health (NIH); United States Department of Health & Human Services; National Institutes of Health (NIH) - USA R01NS115831; R35CA197718; R01CA238662; R01NS103434 / NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA Michael Mosier Defeat DIPG Foundation RSNA V Foundation
- Language
- English
- Date published
- 09/01/2022
- Academic Unit
- Radiation Oncology
- Record Identifier
- 9984696571302771
Metrics
12 Record Views