Brain-derived neurotrophic factor gene Val66Met polymorphism and cognitive function in obsessive-compulsive disorder

Raşit Tükel; Hakan Gürvit; Berna Ozata; Nalan Oztürk; Banu A Ertekin; Erhan Ertekin; Bengi Baran; Sükriye A Kalem; Deniz Büyükgök; Güher S Direskeneli

doi:10.1002/ajmg.b.32092

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Brain-derived neurotrophic factor gene Val66Met polymorphism and cognitive function in obsessive-compulsive disorder

Journal article

Peer reviewed

Brain-derived neurotrophic factor gene Val66Met polymorphism and cognitive function in obsessive-compulsive disorder

Raşit Tükel, Hakan Gürvit, Berna Ozata, Nalan Oztürk, Banu A Ertekin, Erhan Ertekin, Bengi Baran, Sükriye A Kalem, Deniz Büyükgök and Güher S Direskeneli

American journal of medical genetics. Part B, Neuropsychiatric genetics, Vol.159B(7), pp.850-858

10/2012

DOI: 10.1002/ajmg.b.32092

PMID: 22911909

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Abstract

In the present study, we have tested the hypothesis that brain-derived neurotrophic factor (BDNF) gene Val66Met polymorphism is associated with obsessive-compulsive disorder (OCD) and also investigated the association between the BDNF Val66Met polymorphism and the performance on tests measuring executive functions in a sample of patients with OCD. A total of 100 patients diagnosed with OCD according to DSM-IV criteria and 110 control subjects were included in this study. Single nucleotide polymorphism (G/A) leading to Val to Met substitution at codon 66 in BDNF was screened in the DNA samples of all participants. The genotype frequencies of BDNF Val66Met polymorphism were compared in OCD patients and healthy controls. The four subgroups of OCD and healthy control subjects, determined according to being Val homozygous or carrying a Met allele, were also compared according to their performance in a battery of neuropsychological tests of executive functions and verbal memory. There was no significant difference for the allele and genotype distributions of BDNF Val66Met polymorphism between the OCD and healthy control groups. Compared to the other three subgroups, OCD-Met carriers were slower on Trail-Making Test part A (TMT A), part B (TMT B) score and its speed-corrected score (TMT B-A). OCD-Met carriers had also poor performance on verbal fluency tasks and several CVLT measures compared only to the healthy control-Met carriers. These results demonstrate that the BDNF Val66Met polymorphism does not appear to be a risk factor for OCD. However, the presence of a BDNF Met allele, which is a known attenuator of BDNF activity, may be associated with a poorer executive functioning in OCD.

Brain-Derived Neurotrophic Factor - genetics

Genetic Predisposition to Disease

Humans

Middle Aged

Male

Cognition

Neuropsychological Tests

Obsessive-Compulsive Disorder - genetics

Adolescent

Alleles

Adult

Valine - genetics

Polymorphism, Single Nucleotide

Methionine - genetics

Details

Title: Subtitle: Brain-derived neurotrophic factor gene Val66Met polymorphism and cognitive function in obsessive-compulsive disorder
Creators: Raşit Tükel - Istanbul Faculty of Medicine, Department of Psychiatry, Istanbul University, Istanbul, Turkey. rtukel@gmail.com
Hakan Gürvit
Berna Ozata
Nalan Oztürk
Banu A Ertekin
Erhan Ertekin
Bengi Baran
Sükriye A Kalem
Deniz Büyükgök
Güher S Direskeneli
Resource Type: Journal article
Publication Details: American journal of medical genetics. Part B, Neuropsychiatric genetics, Vol.159B(7), pp.850-858
DOI: 10.1002/ajmg.b.32092
PMID: 22911909
NLM abbreviation: Am J Med Genet B Neuropsychiatr Genet
ISSN: 1552-4841
eISSN: 1552-485X
Publisher: United States
Language: English
Date published: 10/2012
Academic Unit: Psychiatry; Psychological and Brain Sciences; Iowa Neuroscience Institute; Center for Social Science Innovation
Record Identifier: 9984065375802771

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