Journal article
Brain functional networks: correlation analysis with clinical indexes in patients with diabetic retinopathy
Neuroradiology, Vol.59(11), pp.1121-1131
11/2017
DOI: 10.1007/s00234-017-1900-5
PMID: 28831531
Abstract
The relationship between parameters of brain functional networks and clinical indexes is unclear so far in patients with diabetic retinopathy (DR). This paper is to investigate this.
Twenty-one patients with different grades of DR and 21 age- and sex-matched healthy controls were enrolled from August 2012 to September 2014. The clinical indexes recorded included DR grade, duration of diabetes, HbA1c, diabetic foot screen, fasting plasma glucose, insulin, Homa-β, Homa-IR, insulin sensitive index (ISI), Mini-Mental State Examination (MMSE), and patient sex and age. Subjects were scanned using 3-T MR with blood-oxygen-level-dependent and 3D-FSPGR sequences. MR data was analyzed via preprocessing and functional network construction, and quantified indexes of network (clustering coefficient, characteristic path length, global efficiency, degree distribution, and small worldness) were evaluated. Statistics consisted of ANOVA and correlation.
There were significant differences between patients and controls among clustering coefficient, characteristic path length, degree distribution, and small worldness parameters (P < 0.05). MMSE scores negatively correlated with characteristic path length, and Hb1Ac negatively correlated with small worldness. MMSE, duration of diabetes, diabetic foot screen, fasting plasma glucose, insulin, Homa-β, Homa-IR, ISI, DR grade, and patient age, except from Hb1Ac, correlated with degree distribution in certain brain areas.
Brain functional networks are altered, specifically in the areas of visual function and cognition, and these alterations may reflect the severity of visual weakness and cognitive decline in DR patients. Moreover, the brain networks may be affected both by long-standing and instant clinical factors.
Details
- Title: Subtitle
- Brain functional networks: correlation analysis with clinical indexes in patients with diabetic retinopathy
- Creators
- Hui Dai - First Affiliated Hospital of Soochow UniversityYu Zhang - First Affiliated Hospital of Soochow UniversityLillian Lai - LAC+USC Medical CenterSu Hu - First Affiliated Hospital of Soochow UniversityXiming Wang - First Affiliated Hospital of Soochow UniversityYonggang Li - First Affiliated Hospital of Soochow UniversityChunhong Hu - First Affiliated Hospital of Soochow UniversityHailin Shen - Suzhou Kowloon Hospital
- Resource Type
- Journal article
- Publication Details
- Neuroradiology, Vol.59(11), pp.1121-1131
- DOI
- 10.1007/s00234-017-1900-5
- PMID
- 28831531
- ISSN
- 0028-3940
- eISSN
- 1432-1920
- Grant note
- JS-2014-197 / Jiangsu Provincial Department of Education Q201303 / Medical Research Projects of the Department of Health, Jiangsu province 81201079 / National Natural Science Foundation of China
- Language
- English
- Date published
- 11/2017
- Academic Unit
- Radiology
- Record Identifier
- 9984318723102771
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