Journal article
Brain magnetic resonance imaging with contrast dependent on blood oxygenation
Proceedings of the National Academy of Sciences - PNAS, Vol.87(24), pp.9868-9872
12/1990
DOI: 10.1073/pnas.87.24.9868
PMID: 2124706
Abstract
Paramagnetic deoxyhemoglobin in venous blood is a naturally occurring contrast agent for magnetic resonance imaging (MRI). By accentuating the effects of this agent through the use of gradient-echo techniques in high fields, we demonstrate in vivo images of brain microvasculature with image contrast reflecting the blood oxygen level. This blood oxygenation level-dependent (BOLD) contrast follows blood oxygen changes induced by anesthetics, by insulin-induced hypoglycemia, and by inhaled gas mixtures that alter metabolic demand or blood flow. The results suggest that BOLD contrast can be used to provide in vivo real-time maps of blood oxygenation in the brain under normal physiological conditions. BOLD contrast adds an additional feature to magnetic resonance imaging and complements other techniques that are attempting to provide positron emission tomography-like measurements related to regional neural activity.
Details
- Title: Subtitle
- Brain magnetic resonance imaging with contrast dependent on blood oxygenation
- Creators
- S Ogawa - Biophysics Research Department, AT&T Bell Laboratories, Murray Hill, NJ 07974T M LeeA R KayD W Tank
- Resource Type
- Journal article
- Publication Details
- Proceedings of the National Academy of Sciences - PNAS, Vol.87(24), pp.9868-9872
- Publisher
- United States
- DOI
- 10.1073/pnas.87.24.9868
- PMID
- 2124706
- ISSN
- 0027-8424
- eISSN
- 1091-6490
- Language
- English
- Date published
- 12/1990
- Academic Unit
- Iowa Neuroscience Institute; Biology
- Record Identifier
- 9983991973802771
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