Brain parenchymal infection in bone marrow transplantation patients : CT and MR findings

William T C Yuh; Hoang D Nguyen; Feng Gao; E. Turgut Tali; D. J FISHER; Nina A Mayr; Donald P Mueller; Yutaka Sato; Michael E Trigg; Roger Gingrich

doi:10.2214/ajr.162.2.8310939

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Brain parenchymal infection in bone marrow transplantation patients : CT and MR findings

Journal article

Open access

Peer reviewed

Brain parenchymal infection in bone marrow transplantation patients : CT and MR findings

William T C Yuh, Hoang D Nguyen, Feng Gao, E. Turgut Tali, D. J FISHER, Nina A Mayr, Donald P Mueller, Yutaka Sato, Michael E Trigg and Roger Gingrich

American journal of roentgenology (1976), Vol.162(2), pp.425-430

1994

DOI: 10.2214/ajr.162.2.8310939

PMID: 8310939

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Abstract

The purpose of this study was to assess the MR and CT appearance of brain infection after bone marrow transplantation and to correlate the appearances with laboratory and pathologic findings. We retrospectively reviewed the records of seven bone marrow transplant recipients with radiologic evidence of brain infection. Forty-one lesions were detected in seven patients with proved infectious foci outside the brain before brain infection was suspected clinically. Six patients had low total WBC or lymphocyte counts and one patient had normal total WBC and lymphocyte counts. Most lesions in patients with low total WBC or lymphocyte counts showed no appreciable edema or contrast enhancement. However, all lesions detected in the patient with normal total WBC and lymphocyte counts showed marked vasogenic edema and ring enhancement. Brain infection in bone marrow transplant recipients during immunosuppression exhibited MR characteristics different from those typically seen in immunocompetent patients. This appearance may be related to a diminished immunologic/inflammatory response.

Biological and medical sciences

Medical sciences

Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy

Bone marrow, stem cells transplantation. Graft versus host reaction

Transfusions. Complications. Transfusion reactions. Cell and gene therapy

Details

Title: Subtitle: Brain parenchymal infection in bone marrow transplantation patients : CT and MR findings
Creators: William T C Yuh - Univ. Iowa coll. medicine, dep. radiology, Iowa City IA 52242, United States
Hoang D Nguyen - Univ. Iowa coll. medicine, dep. radiology, Iowa City IA 52242, United States
Feng Gao - Univ. Iowa coll. medicine, dep. radiology, Iowa City IA 52242, United States
E. Turgut Tali - Univ. Iowa coll. medicine, dep. radiology, Iowa City IA 52242, United States
D. J FISHER - Univ. Iowa coll. medicine, dep. radiology, Iowa City IA 52242, United States
Nina A Mayr - Univ. Iowa coll. medicine, dep. radiology, Iowa City IA 52242, United States
Donald P Mueller - Univ. Iowa coll. medicine, dep. radiology, Iowa City IA 52242, United States
Yutaka Sato - Univ. Iowa coll. medicine, dep. radiology, Iowa City IA 52242, United States
Michael E Trigg - Univ. Iowa coll. medicine, dep. radiology, Iowa City IA 52242, United States
Roger Gingrich - University of Iowa, Internal Medicine
Resource Type: Journal article
Publication Details: American journal of roentgenology (1976), Vol.162(2), pp.425-430
DOI: 10.2214/ajr.162.2.8310939
PMID: 8310939
NLM abbreviation: AJR Am J Roentgenol
ISSN: 0361-803X
eISSN: 1546-3141
Publisher: American Roentgen Ray Society; Leesburg, VA
Language: English
Date published: 1994
Academic Unit: Radiology; Hematology, Oncology, and Blood & Marrow Transplantation; Stead Family Department of Pediatrics; Internal Medicine
Record Identifier: 9984051876802771

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