Journal article
Brain serotonin transporter distribution in subjects with impulsive aggressivity : A positron emission study with [11C]McN 5652
The American journal of psychiatry, Vol.162(5), pp.915-923
2005
DOI: 10.1176/appi.ajp.162.5.915
PMID: 15863793
Abstract
Objective: The serotonin system is believed to play a role in modulating impulsivity and violence. Previous imaging studies have implicated the anterior cingulate and orbitofrontal cortex in impulsive aggression. This study evaluated regional serotonin transporter distribution in the brain of individuals with impulsive aggression by using positron emission tomography (PET) with the serotonin transporter PET radiotracer [11C]McN 5652. Method: Ten individuals with impulsive aggression and 10 age- and sex-matched healthy comparison subjects underwent [11C]McN 5652 PET. All individuals were medication free at the time of scanning. Regional total distribution volumes were derived by using a one-tissue compartment kinetic model with arterial input function. Outcome measures of serotonin transporter availability included the binding potential and the specific-to-nonspecific partition coefficient (V 3″). Results: Serotonin transporter availability was significantly reduced in the anterior cingulate cortex of individuals with impulsive aggression compared with healthy subjects, as noted by differences in both binding potential (mean=3.1 ml/g [SD=1.9] versus 5.0 ml/g [SD=2.0], respectively) and V3″ (mean=0.15 [SD=0.09] versus 0.26 [SD=0.09]). In other regions examined, serotonin transporter density was nonsignificantly lower in individuals with impulsive aggression compared with healthy subjects. Conclusions: Pathological impulsive aggressivity might be associated with lower serotonergic innervation in the anterior cingulate cortex, a region that plays an important role in affective regulation.
Details
- Title: Subtitle
- Brain serotonin transporter distribution in subjects with impulsive aggressivity : A positron emission study with [11C]McN 5652
- Creators
- W. Gordon Frankle - Columbia UniversityIlise Lombardo - Icahn School of Medicine at Mount SinaiMarc Laruelle - Icahn School of Medicine at Mount SinaiLarry J Siever - Icahn School of Medicine at Mount SinaiAntonia S New - Icahn School of Medicine at Mount SinaiMarianne Goodman - Icahn School of Medicine at Mount SinaiPeter S Talbot - Icahn School of Medicine at Mount SinaiYIYUN Huang - Icahn School of Medicine at Mount SinaiDah-Ren Hwang - Icahn School of Medicine at Mount SinaiMark Slifstein - Icahn School of Medicine at Mount SinaiSusan Curry - Icahn School of Medicine at Mount SinaiAnissa ABI-DARGHAM - Icahn School of Medicine at Mount Sinai
- Resource Type
- Journal article
- Publication Details
- The American journal of psychiatry, Vol.162(5), pp.915-923
- Publisher
- American Psychiatric Association
- DOI
- 10.1176/appi.ajp.162.5.915
- PMID
- 15863793
- ISSN
- 0002-953X
- eISSN
- 1535-7228
- Language
- English
- Date published
- 2005
- Academic Unit
- Health Management and Policy; Community and Behavioral Health
- Record Identifier
- 9984366373302771
Metrics
21 Record Views