Brain stem mechanisms and the inhibition of angiotensin-induced drinking

Lynne E Ohman; Alan Kim Johnson

doi:10.1152/ajpregu.1989.256.1.R264

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Brain stem mechanisms and the inhibition of angiotensin-induced drinking

Journal article

Peer reviewed

Brain stem mechanisms and the inhibition of angiotensin-induced drinking

Lynne E Ohman and Alan Kim Johnson

American journal of physiology. Regulatory, integrative and comparative physiology, Vol.256(1), pp.R264-R269

1989

DOI: 10.1152/ajpregu.1989.256.1.R264

PMID: 2912220

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Abstract

The present studies examine the effect of lesions of the ventrolateral region of the lateral parabrachial nucleus (VLLPBN) and of the area postrema and medial region of the nucleus of the solitary tract (AP/mNTS) on water intake induced by intracerebroventricular administration of angiotensin II (ANG II) and of the cholinergic receptor agonist, carbachol. Water intake was measured in rats with bilateral electrolytic lesions of the VLLPBN or thermocautery ablation of the AP/mNTS after intracerebroventricular delivery of ANG II (50 and 100 ng/2 microliter), carbachol (100 and 250 ng/2 microliter), and isotonic saline (2 microliter). Rats with lesions of the VLLPBN drank significantly more water during a 30-min test period to both doses of ANG II, but not to carbachol, than did sham lesion rats. Similarly, AP/mNTS lesion rats drank significantly more than sham lesion animals in response to the high dose of ANG II but not to carbachol. These results suggest that the previously reported exaggerated drinking responses to systemically administered ANG II demonstrated by rats with either VLLPBN or AP/mNTS lesions is not the result of a direct peripheral action of the octapeptide. Furthermore, the similarity of the induced drinking responses produced by these two lesions suggests that the AP/mNTS and the VLLPBN may be linked in a common thirst-mediating pathway.

Biological and medical sciences

Feeding. Feeding behavior

Fundamental and applied biological sciences. Psychology

Vertebrates: anatomy and physiology, studies on body, several organs or systems

Details

Title: Subtitle: Brain stem mechanisms and the inhibition of angiotensin-induced drinking
Creators: Lynne E Ohman - Univ. Iowa, dep. psychology, Iowa City IA 52242, United States
Alan Kim Johnson - Univ. Iowa, dep. psychology, Iowa City IA 52242, United States
Resource Type: Journal article
Publication Details: American journal of physiology. Regulatory, integrative and comparative physiology, Vol.256(1), pp.R264-R269
DOI: 10.1152/ajpregu.1989.256.1.R264
PMID: 2912220
NLM abbreviation: Am J Physiol Regul Integr Comp Physiol
ISSN: 0363-6119
eISSN: 1522-1490
Publisher: American Physiological Society
Language: English
Date published: 1989
Academic Unit: Psychological and Brain Sciences; Neuroscience and Pharmacology; Health, Sport, and Human Physiology
Record Identifier: 9984213280102771

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