Brain structure and cognition in a community sample of elderly Latinos

C C Wu; D Mungas; C I Petkov; J L Eberling; P A Zrelak; M H Buonocore; J A Brunberg; M N Haan; W J Jagust

doi:10.1212/WNL.59.3.383

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Brain structure and cognition in a community sample of elderly Latinos

Journal article

Peer reviewed

Brain structure and cognition in a community sample of elderly Latinos

C C Wu, D Mungas, C I Petkov, J L Eberling, P A Zrelak, M H Buonocore, J A Brunberg, M N Haan and W J Jagust

Neurology, Vol.59(3), pp.383-391

08/13/2002

DOI: 10.1212/WNL.59.3.383

PMID: 12177372

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Abstract

Previous studies have found that hippocampal atrophy and white matter hyperintensities (WMH) on MRI are linked to cognitive impairment and dementia. The authors measured these variables in a population-based cohort of older Mexican Americans with a wide spectrum of cognitive ability, ranging from normal cognition to dementia. To investigate whether these structural brain changes were seen in individuals prior to the development of dementia and how these changes were related to the presence of dementia. A sample of 122 subjects was selected from the Sacramento Area Latino Study on Aging, and subjects were categorized into four groups of increasing levels of cognitive impairment: normal, memory impaired (MI), cognitively impaired but not demented (CIND), and demented. Hippocampal volume was quantified using a region of interest approach. WMH was rated on a semiquantitative scale as the percent of total volume of white matter. Hippocampal volume was significantly reduced in CIND and demented individuals, and WMH were significantly increased in demented subjects. MI subjects did not have any significant changes in hippocampal volume or WMH. The risk for developing dementia was significantly and comparably increased in subjects with either hippocampal atrophy or high WMH. However, the risk for dementia increased dramatically in subjects with both hippocampal atrophy and a high degree of WMH. Reductions in hippocampal volume may be present before dementia but not until cognitive impairment is relatively severe. Because there is a synergistic effect between high WMH and hippocampal atrophy, interactions between vascular and degenerative processes may be important determinants of dementia.

Aged

Aged, 80 and over

Aging - physiology

Aging - psychology

Analysis of Variance

Atrophy

Brain - pathology

Chi-Square Distribution

Cognition Disorders - diagnosis

Cognition Disorders - epidemiology

Cohort Studies

Confidence Intervals

Data Collection - methods

Data Collection - statistics & numerical data

Female

Hippocampus - pathology

Humans

Logistic Models

Magnetic Resonance Imaging

Male

Mexican Americans - psychology

Mexican Americans - statistics & numerical data

Middle Aged

Odds Ratio

Details

Title: Subtitle: Brain structure and cognition in a community sample of elderly Latinos
Creators: C C Wu - University of California Davis Medical Center
D Mungas
C I Petkov
J L Eberling
P A Zrelak
M H Buonocore
J A Brunberg
M N Haan
W J Jagust
Resource Type: Journal article
Publication Details: Neurology, Vol.59(3), pp.383-391
DOI: 10.1212/WNL.59.3.383
PMID: 12177372
ISSN: 0028-3878
eISSN: 1526-632X
Grant note: R01 DK060753 / NIDDK NIH HHS R01 AG012975 / NIA NIH HHS R03 AG033751 / NIA NIH HHS AG 10129 / NIA NIH HHS AG 10220 / NIA NIH HHS AG 12975 / NIA NIH HHS
Language: English
Date published: 08/13/2002
Academic Unit: Iowa Neuroscience Institute; Neurosurgery; Otolaryngology
Record Identifier: 9984360008202771

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