Journal article
Brain uptake and utilization of fatty acids: Applications to peroxisomal biogenesis diseases
Journal of molecular neuroscience, Vol.16(2), pp.87-92
06/2001
DOI: 10.1385/JMN:16:2-3:87
PMID: 11478388
Abstract
The brain is rich in diverse fatty acids saturated, monounsaturated and polyunsaturated fatty acids with chain lengths ranging from less than 16 to more than 24 carbons that make up the complex lipids present in this organ. While some fatty acids are derived from endogenous synthesis, others must come from exogenous sources. The mechanism(s) by which fatty acids enter cells has been the subject of much debate. While some investigators argue for a protein-mediated process, others suggest that simple diffusion is sufficient. In the brain, uptake is further complicated by the presence of the blood-brain barrier. Brain fatty acid homeostasis is disturbed in many human disorders, as typified by the peroxisomal biogenesis diseases. A workshop designed to bring together researchers from varied backgrounds to discuss these issues in an open forum was held in March, 2000. In addition to assessing the current state of knowledge, areas requiring additional investigation were identified and recommendations for future research were made. A brief overview of the invited talks is presented here.
Details
- Title: Subtitle
- Brain uptake and utilization of fatty acids: Applications to peroxisomal biogenesis diseases
- Creators
- Paul A Watkins - Kennedy Krieger Institute 707 N. Broadway 21205 Baltimore MDJames A Hamilton - Boston University School of Medicine Boston MAAlexander Leaf - Harvard Medical School Charlestown MAArthur A Spector - University of Iowa Iowa City IASteven A Moore - University of Iowa Iowa City IARobert E Anderson - University of Oklahoma Health Science Center Oklahoma City OKHugo W Moser - Kennedy Krieger Institute 707 N. Broadway 21205 Baltimore MDMichael J Noetzel - Washington University School of Medicine St. Louis MORobert Katz - Omega-3 Research Institute, Inc. Bethesda MD
- Resource Type
- Journal article
- Publication Details
- Journal of molecular neuroscience, Vol.16(2), pp.87-92
- Publisher
- Humana Press; Totowa
- DOI
- 10.1385/JMN:16:2-3:87
- PMID
- 11478388
- ISSN
- 0895-8696
- eISSN
- 1559-1166
- Language
- English
- Date published
- 06/2001
- Academic Unit
- Pathology; Biochemistry and Molecular Biology; Internal Medicine
- Record Identifier
- 9984047794602771
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