Journal article
Break Induced Replication: the where, the why, and the how
Trends in genetics, Vol.34(7), pp.518-531
07/2018
DOI: 10.1016/j.tig.2018.04.002
PMCID: PMC6469874
PMID: 29735283
Abstract
Break induced replication (BIR) is a pathway that repairs one-ended double strand breaks (DSBs). For decades, yeast model systems offered the only opportunities to study eukaryotic BIR. These studies described an unusual mode of BIR synthesis that is carried out by a migrating bubble and shows conservative inheritance of newly synthesized DNA, leading to genomic instabilities like those associated with cancer in humans. Yet, evidence of BIR functioning in mammals or during repair of other DNA breaks has been missing. Recent studies have uncovered multiple examples of BIR working in replication restart and repair of eroded telomeres in yeast and mammals as well as some unexpected findings, including the
RAD51
independence of BIR. Strong interest remains in determining the variations in molecular mechanisms that drive and regulate BIR in different genetic backgrounds, across organisms, and particularly in the context of human disease.
Details
- Title: Subtitle
- Break Induced Replication: the where, the why, and the how
- Creators
- J KramaraB OsiaA Malkova
- Resource Type
- Journal article
- Publication Details
- Trends in genetics, Vol.34(7), pp.518-531
- DOI
- 10.1016/j.tig.2018.04.002
- PMID
- 29735283
- PMCID
- PMC6469874
- NLM abbreviation
- Trends Genet
- ISSN
- 0168-9525
- eISSN
- 1362-4555
- Language
- English
- Date published
- 07/2018
- Academic Unit
- Stead Family Department of Pediatrics; Biology; Infectious Disease (Pediatrics)
- Record Identifier
- 9984217542602771
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