Journal article
Break-induced replication: functions and molecular mechanism
Current opinion in genetics & development, Vol.23(3), pp.271-279
06/2013
DOI: 10.1016/j.gde.2013.05.007
PMCID: PMC3915057
PMID: 23790415
Abstract
Break-induced replication (BIR) is the pathway of homologous recombination (HR) conserved from phages to eukaryotes that serves to repair DNA breaks that have only one end. BIR contributes to the repair of broken replication forks and allows telomere lengthening in the absence of telomerase. Nonallelic BIR may lead to translocations and other chromosomal rearrangements. In addition, BIR initiated at sites of microhomology can generate copy number variations (CNVs) and complex chromosomal changes. The level of mutagenesis associated with DNA synthesis in BIR is significantly higher than during normal replication. These features make BIR a likely pathway to promote bursts of genetic changes that fuel cancer progression and evolution.
Details
- Title: Subtitle
- Break-induced replication: functions and molecular mechanism
- Creators
- Anna Malkova - Department of Biology, School of Science, IUPUI, Indianapolis, IN 46202, USA. amalkova@iupui.eduGrzegorz Ira
- Resource Type
- Journal article
- Publication Details
- Current opinion in genetics & development, Vol.23(3), pp.271-279
- DOI
- 10.1016/j.gde.2013.05.007
- PMID
- 23790415
- PMCID
- PMC3915057
- NLM abbreviation
- Curr Opin Genet Dev
- ISSN
- 0959-437X
- eISSN
- 1879-0380
- Publisher
- England
- Grant note
- R01 GM080600 / NIGMS NIH HHS GM080600 / NIGMS NIH HHS GM084242 / NIGMS NIH HHS R01 GM084242 / NIGMS NIH HHS
- Language
- English
- Date published
- 06/2013
- Academic Unit
- Biology
- Record Identifier
- 9983992095702771
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