Journal article
Break-induced replication: unraveling each step
Trends in genetics, Vol.38(7), pp.752-765
04/19/2022
DOI: 10.1016/j.tig.2022.03.011
PMCID: PMC9197877
PMID: 35459559
Abstract
Break-induced replication (BIR) repairs one-ended double-strand DNA breaks through invasion into a homologous template followed by DNA synthesis. Different from S-phase replication, BIR copies the template DNA in a migrating displacement loop (D-loop) and results in conservative inheritance of newly synthesized DNA. This unusual mode of DNA synthesis makes BIR a source of various genetic instabilities like those associated with cancer in humans. This review focuses on recent progress in delineating the mechanism of Rad51-dependent BIR in budding yeast. In addition, we discuss new data that describe changes in BIR efficiency and fidelity on encountering replication obstacles as well as the implications of these findings for BIR-dependent processes such as telomere maintenance and the repair of collapsed replication forks.
Details
- Title: Subtitle
- Break-induced replication: unraveling each step
- Creators
- Liping Liu - University of IowaAnna Malkova - Department of Biology, University of Iowa, Iowa City, IA 52242, USA. Electronic address: anna-malkova@uiowa.edu
- Resource Type
- Journal article
- Publication Details
- Trends in genetics, Vol.38(7), pp.752-765
- DOI
- 10.1016/j.tig.2022.03.011
- PMID
- 35459559
- PMCID
- PMC9197877
- NLM abbreviation
- Trends Genet
- ISSN
- 0168-9525
- Grant note
- DOI: 10.13039/100000057, name: National Institute of General Medical Sciences, award: R35GM127006
- Language
- English
- Electronic publication date
- 04/19/2022
- Academic Unit
- Biology
- Record Identifier
- 9984244594502771
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