Journal article
Breast cancer patients from the Midwest region of the United States have reduced levels of short-chain fatty acid-producing gut bacteria
Scientific reports, Vol.13(1), pp.526-526
01/11/2023
DOI: 10.1038/s41598-023-27436-3
PMCID: PMC9834383
PMID: 36631533
Abstract
As geographical location can impact the gut microbiome, it is important to study region-specific microbiome signatures of various diseases. Therefore, we profiled the gut microbiome of breast cancer (BC) patients of the Midwestern region of the United States. The bacterial component of the gut microbiome was profiled utilizing 16S ribosomal RNA sequencing. Additionally, a gene pathway analysis was performed to assess the functional capabilities of the bacterial microbiome. Alpha diversity was not significantly different between BC and healthy controls (HC), however beta diversity revealed distinct clustering between the two groups at the species and genera level. Wilcoxon Rank Sum test revealed modulation of several gut bacteria in BC specifically reduced abundance of those linked with beneficial effects such as Faecalibacterium prausnitzii. Machine learning analysis confirmed the significance of several of the modulated bacteria found by the univariate analysis. The functional analysis showed a decreased abundance of SCFA (propionate) production in BC compared to HC. In conclusion, we observed gut dysbiosis in BC with the depletion of SCFA-producing gut bacteria suggesting their role in the pathobiology of breast cancer. Mechanistic understanding of gut bacterial dysbiosis in breast cancer could lead to refined prevention and treatment.
Details
- Title: Subtitle
- Breast cancer patients from the Midwest region of the United States have reduced levels of short-chain fatty acid-producing gut bacteria
- Creators
- Rachel L Shrode - University of IowaJessica E Knobbe - University of IowaNicole Cady - University of MichiganMeeta Yadav - University of IowaJemmie Hoang - University of IowaCatherine Cherwin - University of IowaMelissa Curry - University of IowaRohan Garje - University of IowaPraveen Vikas - University of IowaSonia Sugg - University of IowaSneha Phadke - University of IowaEdward Filardo - Cytonus Therapeutics, Carlsbad, CA, USA.Ashutosh K Mangalam - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Scientific reports, Vol.13(1), pp.526-526
- DOI
- 10.1038/s41598-023-27436-3
- PMID
- 36631533
- PMCID
- PMC9834383
- NLM abbreviation
- Sci Rep
- ISSN
- 2045-2322
- eISSN
- 2045-2322
- Grant note
- ES005605 / NIEHS/NIH P30 1RO1AI137075 / National Institutes of Health/NIAID T32 GM139776 / NIH HHS P30CA086862 / National Cancer Institute/Nation Institute of Health 1I01CX002212 / Veteran Affairs Merit Award
- Language
- English
- Date published
- 01/11/2023
- Academic Unit
- Hematology, Oncology, and Blood & Marrow Transplantation; Pathology; Iowa Neuroscience Institute; Surgery; Nursing; Dental Research; Internal Medicine
- Record Identifier
- 9984359708802771
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