Breast cancer risk following radiotherapy for Hodgkin lymphoma: modification by other risk factors

Deirdre A Hill; Ethel Gilbert; Graça M Dores; Mary Gospodarowicz; Flora E van Leeuwen; Eric Holowaty; Bengt Glimelius; Michael Andersson; Tom Wiklund; Charles F Lynch; Mars Van't Veer; Hans Storm; Eero Pukkala; Marilyn Stovall; Rochelle E Curtis; James M Allan; John D Boice; Lois B Travis

doi:10.1182/blood-2005-04-1535

Back

Breast cancer risk following radiotherapy for Hodgkin lymphoma: modification by other risk factors

Journal article

Open access

Peer reviewed

Breast cancer risk following radiotherapy for Hodgkin lymphoma: modification by other risk factors

Deirdre A Hill, Ethel Gilbert, Graça M Dores, Mary Gospodarowicz, Flora E van Leeuwen, Eric Holowaty, Bengt Glimelius, Michael Andersson, Tom Wiklund, Charles F Lynch, …

Blood, Vol.106(10), pp.3358-3365

11/15/2005

DOI: 10.1182/blood-2005-04-1535

PMCID: PMC1895063

PMID: 16051739

Files and links (1)

url

https://doi.org/10.1182/blood-2005-04-1535View

Published (Version of record) Open Access

Abstract

The importance of genetic and other risk factors in the development of breast cancer after radiotherapy (RT) for Hodgkin lymphoma (HL) has not been determined. We analyzed data from a breast cancer case-control study (105 patients, 266 control subjects) conducted among 3 817 survivors of HL diagnosed at age 30 years or younger in 6 population-based cancer registries. Odds ratios (ORs) and excess relative risks (ERRs) were calculated using conditional regression. Women who received RT exposure (> or = 5 Gy radiation dose to the breast) had a 2.7-fold increased breast cancer risk (95% confidence interval (CI) 1.4-5.2), compared with those given less than 5 Gy. RT exposure (> or = 5 Gy) was associated with an OR of 0.8 (95% CI, 0.2-3.4) among women with a first- or second-degree family history of breast or ovarian cancer, and 5.8 (95% CI, 2.1-16.3) among all other women (interaction P = .03). History of a live birth appeared to increase the breast cancer risk associated with RT among women not treated with ovarian-damaging therapies. Breast cancer risk following RT varied little according to other factors. The additional increased relative risk of breast cancer after RT for HL is unlikely to be larger among women with a family history of breast or ovarian cancer than among other women.

Radiotherapy Dosage

Humans

Middle Aged

Neoplasms, Radiation-Induced - etiology

Risk Factors

Breast Neoplasms - etiology

Neoplasms, Second Primary - mortality

Hodgkin Disease - complications

Neoplasms, Second Primary - etiology

Neoplasms, Radiation-Induced - mortality

Hodgkin Disease - radiotherapy

Hodgkin Disease - mortality

Adult

Breast Neoplasms - mortality

Female

Retrospective Studies

Odds Ratio

Details

Title: Subtitle: Breast cancer risk following radiotherapy for Hodgkin lymphoma: modification by other risk factors
Creators: Deirdre A Hill - Division of Cancer Epidemiology and Genetics and Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA. dahill@salud.unm.edu
Ethel Gilbert
Graça M Dores
Mary Gospodarowicz
Flora E van Leeuwen
Eric Holowaty
Bengt Glimelius
Michael Andersson
Tom Wiklund
Charles F Lynch
Mars Van't Veer
Hans Storm
Eero Pukkala
Marilyn Stovall
Rochelle E Curtis
James M Allan
John D Boice
Lois B Travis
Resource Type: Journal article
Publication Details: Blood, Vol.106(10), pp.3358-3365
Publisher: United States
DOI: 10.1182/blood-2005-04-1535
PMID: 16051739
PMCID: PMC1895063
ISSN: 0006-4971
eISSN: 1528-0020
Language: English
Date published: 11/15/2005
Academic Unit: Epidemiology
Record Identifier: 9983995141302771

Metrics

22 Record Views

77 Times Cited - Web of Science

See more details