Journal article
Breast density (BD) assessment with digital breast tomosynthesis (DBT): Agreement between Quantra™ and 5th edition BI-RADS
Breast (Edinburgh), Vol.30, pp.185-190
12/2016
DOI: 10.1016/j.breast.2016.10.003
PMID: 27769015
Abstract
To assess the agreement between digital breast tomosynthesis (DBT) breast density (BD) assessment made using Quantra™ and fifth edition BI-RADS®.
This board approved study involved BD assessment of 234 women undergoing DBT investigation. BD estimation was performed from the raw DBT images using Quantra™ 3 (v.2.1.1, Hologic, Bedford MA). BI-RADS® assessment was performed using prior digital mammograms displayed simultaneously with 2D images synthesized from DBT by three radiologists using the fifth edition BI-RADS® (A, B, C, D). Kappa (к) was used to assess inter-reader agreement, agreement between Quantra™ and each reader, as well as the majority report of all readers. Receiver Operating Characteristic (ROC) analysis was used to assess the performance of Quantra™ in reproducing the majority BI-RADS® assessment. Data was then grouped into a two-category scale [almost entirely fatty and scattered fibroglandular tissue (A–B) versus heterogeneously dense and extremely dense (C–D)], and a further analysis performed.
Inter-reader agreement varied from fair [0.38 (95%CI: 0.30–0.46)] to substantial [0.68 (95%CI: 0.61–0.75)] on a four-category scale and substantial [0.70 (95%CI: 0.61–0.78)] to almost perfect [0.85 (95%CI: 0.78–0.92)] on a two-category scale. Using the majority report, the agreement between BI-RADS® and Quantra™ was 0.68 (95%CI: 0.59–0.75) on a four-category scale and 0.86 (95%CI: 0.79–0.93) on a two-category scale. Quantra™ distinguished BI-RADS® A–B from C–D with 97.1% sensitivity and 83.1% specificity.
Data demonstrate moderate to substantial agreement in BD assessment between fifth edition BI-RADS® and Quantra™.
•Quantra™ is feasible for breast density assessment with DBT.•Quantra™ demonstrates moderate to substantial agreement with fifth edition BI-RADS®.•Quantra™ can determine whether or not women imaged with DBT have dense breasts.
Details
- Title: Subtitle
- Breast density (BD) assessment with digital breast tomosynthesis (DBT): Agreement between Quantra™ and 5th edition BI-RADS
- Creators
- Ernest U Ekpo - Discipline of Medical Radiation Sciences in the Faculty of Health Sciences and the Brain and Mind Center, The University of Sydney, AustraliaClaudia Mello-Thoms - Discipline of Medical Radiation Sciences in the Faculty of Health Sciences and the Brain and Mind Center, The University of Sydney, AustraliaMary Rickard - Discipline of Medical Radiation Sciences in the Faculty of Health Sciences and the Brain and Mind Center, The University of Sydney, AustraliaPatrick C Brennan - Discipline of Medical Radiation Sciences in the Faculty of Health Sciences and the Brain and Mind Center, The University of Sydney, AustraliaMark F McEntee - Discipline of Medical Radiation Sciences in the Faculty of Health Sciences and the Brain and Mind Center, The University of Sydney, Australia
- Resource Type
- Journal article
- Publication Details
- Breast (Edinburgh), Vol.30, pp.185-190
- DOI
- 10.1016/j.breast.2016.10.003
- PMID
- 27769015
- NLM abbreviation
- Breast
- ISSN
- 0960-9776
- eISSN
- 1532-3080
- Publisher
- Elsevier Ltd
- Language
- English
- Date published
- 12/2016
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiology
- Record Identifier
- 9984051520302771
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