Breast implants following mastectomy in women with early-stage breast cancer: prevalence and impact on survival

Gem M Le; Cynthia D O'Malley; Sally L Glaser; Charles F Lynch; Janet L Stanford; Theresa Hm Keegan; Dee W West

doi:10.1186/bcr974

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Breast implants following mastectomy in women with early-stage breast cancer: prevalence and impact on survival

Journal article

Open access

Breast implants following mastectomy in women with early-stage breast cancer: prevalence and impact on survival

Gem M Le, Cynthia D O'Malley, Sally L Glaser, Charles F Lynch, Janet L Stanford, Theresa Hm Keegan and Dee W West

Breast cancer research : BCR, Vol.7(2), pp.R184-193

2005

DOI: 10.1186/bcr974

PMCID: PMC1064128

PMID: 15743498

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Abstract

Few studies have examined the effect of breast implants after mastectomy on long-term survival in breast cancer patients, despite growing public health concern over potential long-term adverse health effects. We analyzed data from the Surveillance, Epidemiology and End Results Breast Implant Surveillance Study conducted in San Francisco-Oakland, in Seattle-Puget Sound, and in Iowa. This population-based, retrospective cohort included women younger than 65 years when diagnosed with early or unstaged first primary breast cancer between 1983 and 1989, treated with mastectomy. The women were followed for a median of 12.4 years (n = 4968). Breast implant usage was validated by medical record review. Cox proportional hazards models were used to estimate hazard rate ratios for survival time until death due to breast cancer or other causes for women with and without breast implants, adjusted for relevant patient and tumor characteristics. Twenty percent of cases received postmastectomy breast implants, with silicone gel-filled implants comprising the most common type. Patients with implants were younger and more likely to have in situ disease than patients not receiving implants. Risks of breast cancer mortality (hazard ratio, 0.54; 95% confidence interval, 0.43-0.67) and nonbreast cancer mortality (hazard ratio, 0.59; 95% confidence interval, 0.41-0.85) were lower in patients with implants than in those patients without implants, following adjustment for age and year of diagnosis, race/ethnicity, stage, tumor grade, histology, and radiation therapy. Implant type did not appear to influence long-term survival. In a large, population-representative sample, breast implants following mastectomy do not appear to confer any survival disadvantage following early-stage breast cancer in women younger than 65 years old.

Breast Implants

Breast Neoplasms - surgery

Prevalence

Prognosis

California - epidemiology

Humans

Middle Aged

Suicide

Cause of Death

Breast Neoplasms - psychology

Survival Analysis

Mastectomy

Adult

Breast Neoplasms - mortality

Female

Iowa - epidemiology

Retrospective Studies

SEER Program - statistics & numerical data

Neoplasm Staging

Cohort Studies

Details

Title: Subtitle: Breast implants following mastectomy in women with early-stage breast cancer: prevalence and impact on survival
Creators: Gem M Le - Northern California Cancer Center, Fremont, California, USA. gle@nccc.org
Cynthia D O'Malley
Sally L Glaser
Charles F Lynch
Janet L Stanford
Theresa Hm Keegan
Dee W West
Resource Type: Journal article
Publication Details: Breast cancer research : BCR, Vol.7(2), pp.R184-193
DOI: 10.1186/bcr974
PMID: 15743498
PMCID: PMC1064128
NLM abbreviation: Breast Cancer Res
ISSN: 1465-542X
eISSN: 1465-542X
Publisher: England
Grant note: N01 CN005230 / NCI NIH HHS N01-CN-05224 / NCI NIH HHS N01-CN-05229 / NCI NIH HHS
Language: English
Date published: 2005
Academic Unit: Epidemiology
Record Identifier: 9983995144502771

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