Journal article
Breast milk transmission of flaviviruses in the context of Zika virus: A systematic review
Paediatric and perinatal epidemiology, Vol.32(4), pp.358-368
07/2018
DOI: 10.1111/ppe.12478
PMCID: PMC6103797
PMID: 29882971
Abstract
BackgroundSince the Zika virus epidemic in the Americas began in 2015, Zika virus transmission has occurred throughout the Americas. However, limited information exists regarding possible risks of transmission of Zika virus and other flaviviruses through breast feeding and human milk. We conducted a systematic review of the evidence regarding flaviviruses detection in and transmission through milk, specifically regarding Zika virus, Japanese encephalitis virus, tick-borne encephalitis virus, Powassan virus, West Nile virus, dengue virus, and yellow fever virus.
MethodsMedline, Embase, Global Health, CINAHL, Cochrane Library, Scopus, Popline, Virtual Health Library, and WorldCat were searched through June 2017. Two authors independently screened potential studies for inclusion and extracted data. Human and nonhuman (animal) studies describing: 1) confirmed or suspected cases of mother-to-child transmission through milk; or 2) the presence of flavivirus genomic material in milk.
ResultsSeventeen studies were included, four animal models and thirteen observational studies. Dengue virus, West Nile virus, and Zika virus viral ribonucleic acid was detected in human milk, including infectious Zika virus and dengue virus viral particles. Human breast-feeding transmission was confirmed for only yellow fever virus. There was evidence of milk-related transmission of dengue virus, Powassan virus, and West Nile virus in animal studies.
ConclusionsBecause the health advantages of breast feeding are considered greater than the potential risk of transmission, the World Health Organization recommends that mothers with possible or confirmed Zika virus infection or exposure continue to breast feed. This review did not identify any data that might alter this recommendation.
Details
- Title: Subtitle
- Breast milk transmission of flaviviruses in the context of Zika virus: A systematic review
- Creators
- Taylor Z. Mann - Centers for Disease Control and PreventionLisa B. Haddad - Emory UniversityTonya R. Williams - Centers for Disease Control and PreventionSusan L. Hills - Centers for Disease Control and PreventionJennifer S. Read - Centers for Disease Control and PreventionDeborah L. Dee - Centers for Disease Control and PreventionEric J. Dziuban - Centers for Disease Control and PreventionJanice Perez-Padilla - Centers for Disease Control and PreventionDenise J. Jamieson - Centers for Disease Control and PreventionMargaret A. Honein - Centers for Disease Control and PreventionCarrie K. Shapiro-Mendoza - Centers for Disease Control and Prevention
- Resource Type
- Journal article
- Publication Details
- Paediatric and perinatal epidemiology, Vol.32(4), pp.358-368
- Publisher
- Wiley
- DOI
- 10.1111/ppe.12478
- PMID
- 29882971
- PMCID
- PMC6103797
- ISSN
- 0269-5022
- eISSN
- 1365-3016
- Number of pages
- 11
- Grant note
- 1K23HD078153-01A1 / National Institute of Child Health and Human Development; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
- Language
- English
- Date published
- 07/2018
- Academic Unit
- Obstetrics and Gynecology; VPMA - Administration
- Record Identifier
- 9984446430402771
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