Bridging Huntington’s disease research with big data science: Harmonized neuroimaging datasets from multiple studies

Dorian Pustina; Sandhitsu Das; Dan Rozelle; Hans J. Johnson; Rachael I. Scahill; Sarah J. Tabrizi; Nellie Georgiou-Karistianis; Cristina Sampaio; Andrew Wood

doi:10.1162/imag_a_00395

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Bridging Huntington’s disease research with big data science: Harmonized neuroimaging datasets from multiple studies

Journal article

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Bridging Huntington’s disease research with big data science: Harmonized neuroimaging datasets from multiple studies

Dorian Pustina, Sandhitsu Das, Dan Rozelle, Hans J. Johnson, Rachael I. Scahill, Sarah J. Tabrizi, Nellie Georgiou-Karistianis, Cristina Sampaio and Andrew Wood

Imaging neuroscience (Cambridge, Mass.), Vol.2, pp.1-13

12/16/2024

DOI: 10.1162/imag_a_00395

PMCID: PMC12315745

PMID: 40800273

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Abstract

Multiple neuroimaging datasets from Huntington’s disease (HD) studies are publicly available, but these datasets are in various formats, omit imaging metadata, and sometimes contain corrupt scans. We have created a platform to curate, harmonize, and distribute neuroimaging datasets from eight different studies: TRACK-HD, TRACKOn-HD, PREDICT-HD, IMAGE-HD, HD-YAS, SHIELD-HD, PEARL-HD, and LONGPDE10. The platform is organized into three conceptual levels to serve the research community with both raw and processed data. Raw data are converted into Brain Imaging Data Structure (BIDS) format, while processed data are obtained from pipelines such as Freesurfer and fmriprep. Studies that had followed the same participants were combined. After combining studies, the final six BIDS datasets include a total of 2,216 participants and 7,073 sessions. We outline tools, principles, and recommendations for future data management in HD research.

clinical

Data Resource

federation

fmri

modeling

PET

therapeutic

Details

Title: Subtitle: Bridging Huntington’s disease research with big data science: Harmonized neuroimaging datasets from multiple studies
Creators: Dorian Pustina - CHDI Foundation
Sandhitsu Das - Rancho BioSciences (United States)
Dan Rozelle - Rancho BioSciences (United States)
Hans J. Johnson - University of Iowa
Rachael I. Scahill - University College London
Sarah J. Tabrizi - National Hospital for Neurology and Neurosurgery
Nellie Georgiou-Karistianis - Monash University
Cristina Sampaio - CHDI Foundation
Andrew Wood - CHDI Foundation
Resource Type: Journal article
Publication Details: Imaging neuroscience (Cambridge, Mass.), Vol.2, pp.1-13
DOI: 10.1162/imag_a_00395
PMID: 40800273
PMCID: PMC12315745
eISSN: 2837-6056
Publisher: MIT Press
Number of pages: 13
Language: English
Date published: 12/16/2024
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Electrical and Computer Engineering; Psychiatry; The Iowa Institute for Biomedical Imaging; The Iowa Initiative for Artificial Intelligence; Iowa Informatics Initiative
Record Identifier: 9984757746902771

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