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Bridging THC Knowledge Gaps for Safer Roads: A Call for Action
Journal article   Open access   Peer reviewed

Bridging THC Knowledge Gaps for Safer Roads: A Call for Action

Peizhi Li and Guohua An
Clinical pharmacology and therapeutics, Vol.118(3), pp.548-550
09/2025
DOI: 10.1002/cpt.3717
PMCID: PMC12355012
PMID: 40375471
url
https://doi.org/10.1002/cpt.3717View
Published (Version of record) Open Access

Abstract

The rising cases of cannabis-impaired driving present a looming public safety concern that's currently addressed through varying state regulations. However, these regulations are yet validated and lack scientific robustness. One of the roadblocking factors is our insufficient understanding of THC's pharmacokinetics (PK) and pharmacodynamics (PD) due to limited clinical data. Therefore, we call for joint efforts among researchers and policymakers to conduct more comprehensive cannabis PK/PD studies to improve and validate existing cannabis driving regulations.
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