Bridging animal and human models of exercise-induced brain plasticity

Michelle W Voss; Carmen Vivar; Arthur F Kramer; Henriette van Praag

doi:10.1016/j.tics.2013.08.001

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Bridging animal and human models of exercise-induced brain plasticity

Journal article

Open access

Peer reviewed

Bridging animal and human models of exercise-induced brain plasticity

Michelle W Voss, Carmen Vivar, Arthur F Kramer and Henriette van Praag

Trends in cognitive sciences, Vol.17(10), pp.525-544

10/2013

DOI: 10.1016/j.tics.2013.08.001

PMCID: PMC4565723

PMID: 24029446

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Abstract

Significant progress has been made in understanding the neurobiological mechanisms through which exercise protects and restores the brain. In this feature review, we integrate animal and human research, examining physical activity effects across multiple levels of description (neurons up to inter-regional pathways). We evaluate the influence of exercise on hippocampal structure and function, addressing common themes such as spatial memory and pattern separation, brain structure and plasticity, neurotrophic factors, and vasculature. Areas of research focused more within species, such as hippocampal neurogenesis in rodents, also provide crucial insight into the protective role of physical activity. Overall, converging evidence suggests exercise benefits brain function and cognition across the mammalian lifespan, which may translate into reduced risk for Alzheimer's disease (AD) in humans.

Epigenesis, Genetic - physiology

Animals

Neuronal Plasticity - physiology

Brain-Derived Neurotrophic Factor - physiology

Neurogenesis - physiology

Humans

Cognition - physiology

Exercise - physiology

Hippocampus - physiology

Brain - physiology

Intercellular Signaling Peptides and Proteins - physiology

Details

Title: Subtitle: Bridging animal and human models of exercise-induced brain plasticity
Creators: Michelle W Voss - Department of Psychology, The University of Iowa, Iowa City, IA, USA; Aging Mind and Brain Initiative (AMBI), The University of Iowa, Iowa City, IA, USA. Electronic address: michelle-voss@uiowa.edu
Carmen Vivar
Arthur F Kramer
Henriette van Praag
Resource Type: Journal article
Publication Details: Trends in cognitive sciences, Vol.17(10), pp.525-544
DOI: 10.1016/j.tics.2013.08.001
PMID: 24029446
PMCID: PMC4565723
NLM abbreviation: Trends Cogn Sci
ISSN: 1364-6613
eISSN: 1879-307X
Publisher: England
Grant note: R37 AG025667 / NIA NIH HHS 5R37AG025667 / NIA NIH HHS ZIA AG000328-07 / Intramural NIH HHS
Language: English
Date published: 10/2013
Academic Unit: Psychological and Brain Sciences; Iowa Neuroscience Institute
Record Identifier: 9984002486602771

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