Journal article
Broadway 8 system: a multicenter early evaluation of safety, performance, and clinical outcomes in mechanical thrombectomy
Journal of neurointerventional surgery
10/02/2025
DOI: 10.1136/jnis-2025-024067
PMID: 41043866
Abstract
Background Large-bore aspiration catheters are integral to mechanical thrombectomy (MT) for large vessel occlusions (LVOs), offering potential for improved first pass success and faster recanalization.
Objective To assess the clinical performance, efficacy, and safety profile of the Broadway 8 system as a primary aspiration device in MT of LVOs.
Methods This is a multicenter observational study conducted across 8 US comprehensive stroke centers. Efficacy outcomes included first pass effect (FPE), defined as a single-pass modified Treatment In Cerebral Infarction (mTICI) score ≥2c, and successful reperfusion (final mTICI ≥2b). Safety outcomes included device-related complications, symptomatic intracranial hemorrhage (sICH), and inpatient mortality. Functional outcomes included modified Rankin Scale (mRS) at discharge and delta National Institutes of Health Stroke Scale (NIHSS) score. Logistic regression was used to assess predictors of thrombus access and intermediate catheter use.
Results 49 patients were included. The Broadway 8 system reached the thrombus in 44 (89.8%). Median puncture-to-thrombus and puncture-to-reperfusion times were 11 min (IQR 9–18) and 20 min (14–31), respectively. FPE was achieved in 20 (40.8%). Successful reperfusion was achieved in 46/49 (93.8%), with 35 (71.4%) using Broadway 8. sICH occurred in 2 patients (4.1%). Median mRS at discharge was 3.0 (IQR 1.0–4.0); delta NIHSS was 8 (IQR 5–12). Regression analysis showed faster reperfusion when Broadway 8 was used without an intermediate catheter.
Conclusion The Broadway 8 system appears to be a safe and effective frontline aspiration device, demonstrating a safety and efficacy profile comparable to other large-bore aspiration systems that incorporate delivery-assist technology.
Details
- Title: Subtitle
- Broadway 8 system: a multicenter early evaluation of safety, performance, and clinical outcomes in mechanical thrombectomy
- Creators
- Rime Ezzeldin - College of Central FloridaOsman Mir - NYU Langone HealthAdam Delora - Emergency Medicine, HCA Houston, Kingwood, Texas, USASoHyun Boo - West Virginia UniversitySantiago Ortega-Gutierrez - University of Iowa Hospitals and ClinicsJaydevsinh Dolia - Emory UniversityDiogo C Haussen - Emory UniversityClemens Maria Schirmer - Geisinger Health SystemFadi Alsaiegh - The University of Texas Health Science Center at San AntonioJustin Mascitelli - The University of Texas Health Science Center at San AntonioAmeer E Hassan - The University of Texas Rio Grande ValleyMuhammad Waqas Khan - Carondelet Health NetworkJan-Karl Burkhardt - NYU Langone HealthOmar Malik - John Sealy HospitalDaniel Diehl - West Virginia UniversityMario Zanaty - University of IowaAhmed Aljuboori - Geisinger Health SystemSamantha Miller - Valley Baptist Medical CenterVisish M Srinivasan - University of PennsylvaniaKyle Scott - University of PennsylvaniaZuhair Ali - Lone Star College KingwoodMohamad Ezzeldin - University of Houston
- Resource Type
- Journal article
- Publication Details
- Journal of neurointerventional surgery
- DOI
- 10.1136/jnis-2025-024067
- PMID
- 41043866
- NLM abbreviation
- J Neurointerv Surg
- ISSN
- 1759-8478
- eISSN
- 1759-8486
- Publisher
- BMJ Publishing Group Ltd
- Language
- English
- Electronic publication date
- 10/02/2025
- Academic Unit
- Neurology; Radiology; Iowa Neuroscience Institute; Neurosurgery
- Record Identifier
- 9984969242902771
Metrics
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