Journal article
Bronchial hyperreactivity is associated with enhanced grain dust-induced airflow obstruction
Journal of applied physiology (1985), Vol.89(3), pp.1172-1178
09/01/2000
DOI: 10.1152/jappl.2000.89.3.1172
PMID: 10956366
Abstract
Bronchial hyperreactivity (BHR) is associated with the presence of airway inflammation in asthma and is seen in individuals occupationally exposed to grain dust. To better understand the relationship between BHR and pulmonary inflammation after grain dust exposure, we carried out an inhalation challenge to corn dust extract (CDE) on seven subjects with BHR [a 20% or greater decrease in forced expiratory volume in 1 s (FEV1) compared with diluent FEV1 with a cumulative dose of histamine ≤47.3 breath units] and compared their physiological and inflammatory responses with those of seven matched control subjects. BHR subjects were exposed to nebulized CDE (target dose of 0.16 μg/kg endotoxin) as tolerated; matched controls received equal amounts of CDE. Subjects with BHR complained of chest tightness and dyspnea within the 2 h after inhalation of CDE significantly more frequently than controls. Similarly, subjects with BHR developed significantly greater percent declines in FEV1 at time points up to 4 h after exposure to CDE. Significant increases in total cells, neutrophils, tumor necrosis factor-α, interleukin-6, and interleukin-8 were detected in bronchoalveolar lavage fluid 4 h after inhalation of CDE in all subjects, but no differences were detected between the control and BHR groups. These results suggest that, although subjects with BHR develop a more precipitous decline in FEV1 after exposure to CDE, the inflammatory response to CDE is similar in subjects with and without BHR.
Details
- Title: Subtitle
- Bronchial hyperreactivity is associated with enhanced grain dust-induced airflow obstruction
- Creators
- Joel N Kline - Department of Internal Medicine, University of Iowa College of Medicine, Iowa City, Iowa 52242Paul J Jagielo - Department of Internal Medicine, University of Iowa College of Medicine, Iowa City, Iowa 52242Janet L Watt - Department of Internal Medicine, University of Iowa College of Medicine, Iowa City, Iowa 52242David A Schwartz - Department of Internal Medicine, University of Iowa College of Medicine, Iowa City, Iowa 52242
- Resource Type
- Journal article
- Publication Details
- Journal of applied physiology (1985), Vol.89(3), pp.1172-1178
- DOI
- 10.1152/jappl.2000.89.3.1172
- PMID
- 10956366
- ISSN
- 8750-7587
- eISSN
- 1522-1601
- Language
- English
- Date published
- 09/01/2000
- Academic Unit
- Pulmonary, Critical Care, and Occupational Medicine; Occupational and Environmental Health; Internal Medicine
- Record Identifier
- 9984094751302771
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