Brown fat thermogenesis and cardiac rate regulation during cold challenge in infant rats

Mark S Blumberg; Greta Sokoloff; Robert F Kirby

doi:10.1152/ajpregu.1997.272.4.R1308

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Brown fat thermogenesis and cardiac rate regulation during cold challenge in infant rats

Journal article

Peer reviewed

Brown fat thermogenesis and cardiac rate regulation during cold challenge in infant rats

Mark S Blumberg, Greta Sokoloff and Robert F Kirby

The American journal of physiology, Vol.272(4 Pt 2), pp.R1308-1313

04/1997

DOI: 10.1152/ajpregu.1997.272.4.R1308

PMID: 9140034

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Abstract

Infants rats depend on heat production by brown adipose tissue (BAT) during cold challenge. Although it has been suggested that BAT thermogenesis protects the heart in the cold, the relationship of BAT activation to cardiac rate has not been examined directly. In the first experiment, the cardiac rate of 2- and 7- to 8-day-old rat pups was monitored during moderate and extreme cold challenge. Pups at both ages maintained cardiac rate during moderate cold challenge while BAT thermogenesis was increasing. In contrast, cooling to air temperatures at which BAT thermogenesis could increase no further resulted in pronounced bradycardia. In the second experiment, ganglionic blockade was used to eliminate BAT heat production and autonomic control of the heart in 7- to 8-day olds. Blockade suppressed BAT thermogenesis in the cold and led to pronounced decreases in interscapular temperature and cardiac rate. These data suggest that cardiac rate in infant rats is modulated both by the autonomic nervous system and BAT thermogenesis.

Animals, Newborn

Heart Rate

Cold Temperature

Temperature

Body Temperature Regulation

Oxygen Consumption

Adipose Tissue, Brown - physiology

Rats

Acclimatization

Male

Body Temperature

Ganglia, Autonomic - physiology

Animals

Aging - physiology

Adipose Tissue, Brown - growth & development

Electrocardiography

Details

Title: Subtitle: Brown fat thermogenesis and cardiac rate regulation during cold challenge in infant rats
Creators: Mark S Blumberg - Department of Psychology, University of Iowa, Iowa City 52242, USA
Greta Sokoloff
Robert F Kirby
Resource Type: Journal article
Publication Details: The American journal of physiology, Vol.272(4 Pt 2), pp.R1308-1313
DOI: 10.1152/ajpregu.1997.272.4.R1308
PMID: 9140034
NLM abbreviation: Am J Physiol
ISSN: 0002-9513
eISSN: 2163-5773
Publisher: United States
Grant note: MH-50701 / NIMH NIH HHS
Language: English
Date published: 04/1997
Academic Unit: Psychological and Brain Sciences; Iowa Neuroscience Institute; Biology; University College Courses
Record Identifier: 9984002449202771

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