Journal article
Budesonide for Protein Losing Enteropathy in Patients with Fontan Circulation: A Systematic Review and Meta-Analysis
World journal for pediatric & congenital heart surgery, Vol.11(1), pp.85-91
01/01/2020
DOI: 10.1177/2150135119872196
PMID: 31835979
Abstract
Background: Recent studies have shown that oral budesonide can be used to improve albumin level in patients with protein-losing enteropathy (PLE) following Fontan procedure. However, there has never been a systematic review and meta-analysis to confirm this finding. We performed a systematic review and meta-analysis to explore the therapeutic effect of budesonide in patients with PLE post-Fontan procedure. Methods: We searched the databases of MEDLINE and EMBASE from inception to January 2019. Included studies were published studies that evaluate albumin level before and after budesonide therapy in patients with PLE following Fontan procedure. Data from each study were combined using the random-effects model. Results: Five studies with 36 post-Fontan operation patients with PLE were included. In random-effects model, there was a statistically significant difference in albumin level between before and after budesonide treatment (weighted mean difference = 1.28, 95% confidence interval: 0.76-1.79). No publication bias was observed on a funnel plot and Egger test with a P value of .676. Conclusions: The results of this systematic review and meta-analysis show that budesonide can be used to increase albumin level in patients with PLE following Fontan operation. Further studies may focus on the impact of outcome of budesonide in this population.
Details
- Title: Subtitle
- Budesonide for Protein Losing Enteropathy in Patients with Fontan Circulation: A Systematic Review and Meta-Analysis
- Creators
- Jakrin Kewcharoen - University of Hawaii SystemPoemlarp Mekraksakit - Phramongkutklao HospitalNath Limpruttidham - University of Hawaii SystemChanavuth Kanitsoraphan - University of Hawaii SystemNattawat Charoenpoonsiri - Chulalongkorn UniversityKittika Poonsombudlert - University of Hawaii SystemRobert J. Pattison - University of Hawaii SystemPattara Rattanawong - University of Hawaii System
- Resource Type
- Journal article
- Publication Details
- World journal for pediatric & congenital heart surgery, Vol.11(1), pp.85-91
- Publisher
- Sage
- DOI
- 10.1177/2150135119872196
- PMID
- 31835979
- ISSN
- 2150-1351
- eISSN
- 2150-136X
- Number of pages
- 7
- Language
- English
- Date published
- 01/01/2020
- Academic Unit
- Internal Medicine
- Record Identifier
- 9984691517602771
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