Journal article
Bugs in the system: bringing the human microbiome to bear in cancer immunotherapy
Gut Microbes, Vol.10(2), pp.109-112
03/04/2019
DOI: 10.1080/19490976.2018.1511665
PMCID: PMC6546317
PMID: 30183502
Abstract
The influence of the composition of the human microbiome on the efficacy of cancer directed immunotherapies, such as antibodies directed against the programmed cell death 1 protein (PD-1) or its ligand (PD-L1), has garnered increasing attention as the role of immunotherapies in the care of cancer has grown. Dysbiosis (altered microbiota) has recently been reported to adversely affect the efficacy of cancer directed immunotherapies, and correction of this dysbiosis has the potential to improve the efficacy of these treatments. However, the exact mechanisms underlying this relationship remains unknown. Current methods for characterizing the microbiome likely capture only a small portion of the highly complex interaction between the microbiome and the immune system. Here we discuss the recent reports of the influence of dysbiosis on cancer immunotherapy, methods to more fully characterize the interaction between the microbiome and the immune system, and methods of modulating the immune system to improve the efficacy of cancer immunotherapy.
Details
- Title: Subtitle
- Bugs in the system: bringing the human microbiome to bear in cancer immunotherapy
- Creators
- Christopher Strouse - Division of Hematology, Oncology and Blood & Marrow Transplantation, Department of Internal Medicine, Holden Comprehensive Cancer CenterAshutosh Mangalam - Department of Pathology, University of Iowa Carver College of MedicineJun Zhang - Division of Hematology, Oncology and Blood & Marrow Transplantation, Department of Internal Medicine, Holden Comprehensive Cancer Center
- Resource Type
- Journal article
- Publication Details
- Gut Microbes, Vol.10(2), pp.109-112
- Publisher
- Taylor & Francis
- DOI
- 10.1080/19490976.2018.1511665
- PMID
- 30183502
- PMCID
- PMC6546317
- ISSN
- 1949-0976
- eISSN
- 1949-0984
- Grant note
- University of Iowa (10.13039/100008893) American Cancer Society (10.13039/100000048)
- Language
- English
- Date published
- 03/04/2019
- Academic Unit
- Pathology; Iowa Neuroscience Institute; Internal Medicine
- Record Identifier
- 9983905525102771
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