Journal article
Building a growing genomic repository for maternal and fetal health through the PING Consortium
Pediatric research, Vol.98(2), pp.519-531
08/2025
DOI: 10.1038/s41390-024-03793-1
PMCID: PMC12222536
PMID: 39753885
Abstract
Prenatally transmitted viruses can cause severe damage to the developing brain. There is unexplained variability in prenatal brain injury and postnatal neurodevelopmental outcomes, suggesting disease modifiers. Of note, prenatal Zika infection can cause a spectrum of neurodevelopmental disorders, including congenital Zika syndrome. Currently, there is no preventative treatment or cure. The Prenatal Infection and Neurodevelopmental Genetics (PING) Consortium aims to identify modulators of brain injury and adverse neurodevelopmental outcomes for Zika and other prenatal viral infections.
The Consortium pools information from eight multi-site studies conducted at 23 research centers in six countries to build a growing clinical and genomic repository, which is being mined for modifiers of virally induced brain injury. Partners include Children's National Hospital (USA), Instituto Nacional de Salud (Colombia), the Natural History of Zika Virus Infection in Gestation program (Brazil), Zika Instituto Fernandes Figueira (Brazil), the Centers for Disease Control and Prevention, and the National Institutes of Health.
We have enrolled 4102 mothers and 3877 infants with 3063 biological samples and clinical data covering over 80 phenotypic fields and 5000 variables. Thus far, we have performed whole exome sequencing on 1226 participants.
Here, we present the Consortium's formation and overarching study design.
The PING Consortium brings together investigators and institutions to determine the causes of virally induced brain injury and neurological deficits. The clinical and genomic repository, with data from over 8000 patients, will serve as a foundation for a variety of basic and clinical studies.
Details
- Title: Subtitle
- Building a growing genomic repository for maternal and fetal health through the PING Consortium
- Creators
- Clara M Abdelmalek - University of Maryland, College ParkShriya Singh - University of Maryland, College ParkBlain Fasil - Children's NationalAllison R Horvath - Children's NationalSarah B Mulkey - Children's NationalCarlos Curé - BIOMELab, Barranquilla, ColombiaMaribel Campos - University of Puerto Rico, Medical Sciences CampusDenise P Cavalcanti - Universidade Estadual de Campinas (UNICAMP)Van T Tong - Centers for Disease Control and PreventionMarcela Mercado - Universidad del NorteMarcela Daza - Universidad Nacional de ColombiaMónica Marcela Benavides - Instituto Nacional de SaludJacqueline Acosta - Vysnova Partners, Inc., Landover, MD, USASuzanne Gilboa - Centers for Disease Control and PreventionDiana Valencia - Centers for Disease Control and PreventionChristina L Sancken - Centers for Disease Control and PreventionSuzanne Newton - Centers for Disease Control and PreventionDeolinda M F Scalabrin - Gonçalo Moniz Research Center, Oswaldo Cruz Foundation/Ministry of Health, Salvador, BrazilMarisa M Mussi-Pinhata - Universidade de São PauloZilton Vasconcelos - Fundação Oswaldo CruzNahida Chakhtoura - Eunice Kennedy Shriver National Institute of Child Health and Human DevelopmentJack Moye - Eunice Kennedy Shriver National Institute of Child Health and Human DevelopmentElizabeth J Leslie - Emory UniversityDorothy Bulas - George Washington UniversityGilbert Vezina - George Washington UniversityFernanda J P Marques - Sarah Network of Rehabilitation HospitalsMarcio Leyser - University of IowaMiguel Del Campo - Rady Children's Hospital-San DiegoEric Vilain - University of California, IrvineRoberta L DeBiasi - Children's NationalTongguang Wang - National Institute of Neurological Disorders and StrokeAvindra Nath - National Institute of Neurological Disorders and StrokeTarik Haydar - Children's NationalMax Muenke - National Human Genome Research InstituteTamer A Mansour - Mansoura UniversityAdre J du Plessis - George Washington UniversityJeffrey C Murray - University of IowaJosé F Cordero - University of GeorgiaYoussef A Kousa - Children's National
- Resource Type
- Journal article
- Publication Details
- Pediatric research, Vol.98(2), pp.519-531
- DOI
- 10.1038/s41390-024-03793-1
- PMID
- 39753885
- PMCID
- PMC12222536
- NLM abbreviation
- Pediatr Res
- ISSN
- 1530-0447
- eISSN
- 1530-0447
- Publisher
- SPRINGERNATURE
- Grant note
- CDC Disclaimer: The findings and conclusionsNational Institutes of Health (NIH): K08NS119882, R01HD102445
We thank research participants and their families, and the faculty and staff at our institutions. We are also grateful for the support of Children's National Hospital for translational research. CDC Disclaimer: The findings and conclusions in this report are those of the authors and do not necessarily represent the official position of the Centers for Disease Control and Prevention. This study was supported by the National Institutes of Health (NIH) (K08NS119882 to Y.A.K; R01HD102445 to S.B.M.). The funder had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
- Language
- English
- Electronic publication date
- 01/03/2025
- Date published
- 08/2025
- Academic Unit
- Anatomy and Cell Biology; Stead Family Department of Pediatrics; Epidemiology; Pediatric Dentistry; Craniofacial Anomalies Research Center; Developmental and Behavioral Pediatrics; Dental Research
- Record Identifier
- 9984769614302771
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