Journal article
Burkitt Lymphoma in the Mouse
The Journal of experimental medicine, Vol.192(8), pp.1183-1190
10/16/2000
DOI: 10.1084/jem.192.8.1183
PMCID: PMC2195876
PMID: 11034608
Abstract
Chromosomal translocations juxtaposing the MYC protooncogene with regulatory sequences of immunoglobulin (Ig) H chain or kappa (Igκ) or lambda (Igλ) L chain genes and effecting deregulated expression of MYC are the hallmarks of human Burkitt lymphoma (BL). Here we report that lymphomas with striking similarities to BL develop in mice bearing a mutated human MYC gene controlled by a reconstructed Igλ locus encompassing all the elements required for establishment of locus control in vitro. Diffusely infiltrating lymphomas with a typical starry sky appearance occurred in multiple founders and an established line, indicating independence from positional effects. Monoclonal IgM+CD5−CD23− tumors developed from an initially polyclonal population of B cells. These results demonstrate that the phenotype of B lineage lymphomas induced by MYC dysregulation is highly dependent on cooperativity among the regulatory elements that govern expression of the protooncogene and provide a new system for studying the pathogenesis of BL.
Details
- Title: Subtitle
- Burkitt Lymphoma in the Mouse
- Creators
- Alexander L Kovalchuk - Laboratory of Genetics, National Cancer InstituteChen-Feng Qi - Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892Ted A Torrey - Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892Lekidelu Taddesse-Heath - Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892Lionel Feigenbaum - Science Applications International Corporation (SAIC), Frederick Cancer Research Center, National Cancer Institute, National Institutes of Health, Frederick, Maryland 21702Sung Sup Park - Laboratory of Genetics, National Cancer InstituteArmin Gerbitz - Institut für Klinische Molekularbiologie und Tumorgenetik, Munich 81377, GermanyGustav Klobeck - Institut für Physiologische Chemie der Ludwig-Maximilian Universität, Munich 80336, GermanyKonstanze Hoertnagel - Institut für Klinische Molekularbiologie und Tumorgenetik, Munich 81377, GermanyAxel Polack - Institut für Klinische Molekularbiologie und Tumorgenetik, Munich 81377, GermanyGeorg W Bornkamm - Institut für Klinische Molekularbiologie und Tumorgenetik, Munich 81377, GermanySiegfried Janz - Laboratory of Genetics, National Cancer InstituteHerbert C Morse - Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892
- Resource Type
- Journal article
- Publication Details
- The Journal of experimental medicine, Vol.192(8), pp.1183-1190
- DOI
- 10.1084/jem.192.8.1183
- PMID
- 11034608
- PMCID
- PMC2195876
- ISSN
- 0022-1007
- eISSN
- 1540-9538
- Language
- English
- Date published
- 10/16/2000
- Academic Unit
- Pathology
- Record Identifier
- 9984083225202771
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