Journal article
Burkitt lymphoma risk in U.S. solid organ transplant recipients
American journal of hematology, Vol.88(4), pp.245-250
04/2013
DOI: 10.1002/ajh.23385
PMCID: PMC3608801
PMID: 23386365
Abstract
Case reports of Burkitt lymphoma (BL) in transplant recipients suggest that the risk is markedly elevated. Therefore, we investigated the incidence of BL in 203,557 solid organ recipients in the U.S. Transplant Cancer Match Study (1987-2009) and compared it with the general population using standardized incidence ratios. We also assessed associations with demographic and clinical characteristics, and treatments used to induce therapeutic immunosuppression. BL incidence was 10.8 per 100,000 person-years, representing 23-fold (95% confidence interval (CI) 19-28) greater risk than in the general population, and it peaked 3-8 years after the time of transplantation. In adjusted analyses, BL incidence was higher in recipients transplanted when <18 vs. ≥35 years (incidence rate ratio [IRR] 3.49, 95% CI 2.08-5.68) and in those transplanted with a liver (IRR 2.91, 95% CI 1.68-5.09) or heart (IRR 2.39, 95% CI 1.30-4.31) compared with kidney. BL incidence was lower in females than males (IRR 0.45, 95% CI 0.28-0.71), in blacks than whites (IRR 0.33, 95% CI 0.12-0.74), in those with a baseline Epstein-Barr virus (EBV)-seropositive versus EBV-seronegative status (IRR 0.34, 95% CI 0.13-0.93), and in those treated with azathioprine (IRR 0.56, 95% CI 0.34-0.89) or corticosteroids (IRR 0.48, 95% CI 0.29-0.82). Tumors were EBV-positive in 69% of 32 cases with results. EBV positivity was 90% in those aged <18 years and 59% in those aged 18+ years. In conclusion, BL risk is markedly elevated in transplant recipients, and it is associated with certain demographic and clinical features. EBV was positive in most but not all BL cases with results.
Details
- Title: Subtitle
- Burkitt lymphoma risk in U.S. solid organ transplant recipients
- Creators
- Sam M Mbulaiteye - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA. mbulaits@mail.nih.govChristina A ClarkeLindsay M MortonTodd M GibsonKaren PawlishDennis D WeisenburgerCharles F LynchMarc T GoodmanEric A Engels
- Resource Type
- Journal article
- Publication Details
- American journal of hematology, Vol.88(4), pp.245-250
- Publisher
- United States
- DOI
- 10.1002/ajh.23385
- PMID
- 23386365
- PMCID
- PMC3608801
- ISSN
- 0361-8609
- eISSN
- 1096-8652
- Grant note
- N01PC35142 / NCI NIH HHS HHSN261201000024C / NCI NIH HHS U58 DP000807 / NCCDPHP CDC HHS U58 DP000824 / NCCDPHP CDC HHS HHSN261201000036C / NCI NIH HHS U58 DP000848 / NCCDPHP CDC HHS ZIA CP010176-11 / Intramural NIH HHS U58 DP000808 / NCCDPHP CDC HHS HHSN261201000034C / NCI NIH HHS N01PC54405 / NCI NIH HHS T32 CA126607 / NCI NIH HHS N01PC35139 / NCI NIH HHS U58 DP000817 / NCCDPHP CDC HHS N01PC35137 / NCI NIH HHS U58 DP000812 / NCCDPHP CDC HHS HHSN261201000037C / NCI NIH HHS U58 DP000832 / NCCDPHP CDC HHS HHSN261201000035C / NCI NIH HHS N01PC35143 / NCI NIH HHS HHSN261201000026C / NCI NIH HHS U58 DP000805 / NCCDPHP CDC HHS HHSN261201000035I / NCI NIH HHS
- Language
- English
- Date published
- 04/2013
- Academic Unit
- Epidemiology
- Record Identifier
- 9983995145602771
Metrics
25 Record Views