Burkitt s lymphoma variant of post-transplant lymphoproliferative disease (PTLD)

Melissa A Pasquale; Debbie Weppler; Jon Smith; Michael Icardi; Alexandra Amador; Monica Gonzalez; Tomoaki Kato; Andreas Tzakis; Phillip Ruiz

doi:10.1007/BF03033718

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Burkitt s lymphoma variant of post-transplant lymphoproliferative disease (PTLD)

Journal article

Peer reviewed

Burkitt s lymphoma variant of post-transplant lymphoproliferative disease (PTLD)

Melissa A Pasquale, Debbie Weppler, Jon Smith, Michael Icardi, Alexandra Amador, Monica Gonzalez, Tomoaki Kato, Andreas Tzakis and Phillip Ruiz

Pathology oncology research, Vol.8(2), pp.105-108

2002

DOI: 10.1007/BF03033718

PMID: 12172573

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Abstract

The occurrence of posttransplant lymphoproliferative disorder (PTLD) in solid organ allograft recipients can be quite varied in clinical presentation, histopathological characteristics and frequency. A variety of lymphomas can develop as a PTLD although some types appear infrequently and remain poorly understood in this clinical setting. In this report, we describe two cases of Burkitt s lymphoma presenting as a PTLD following liver transplantation. The recipients were 12 and 44 years of age and displayed gastrointestinal involvement by the tumors several years following transplant. The tumors displayed the typical histological features of Burkitt s lymphoma and were markedly positive for EBV. The tumors displayed similar immunophenotypic characteristics by flow cytometry and had rearrangements of the immunoglobulin J-H heavy chain. The tumors required aggressive chemotherapy and a cessation of immunosuppressive therapy. This report demonstrates that Burkitt s type lymphomas can develop in the posttransplant setting and that these tumors contain morphologic, cytofluorographic and molecular features identical to Burkitt s lymphomas that occur in non-transplant patients. Our experience is that these PTLD- Burkitt s lymphomas behave aggressively and require intensive chemotherapeutic intervention.

Flow Cytometry

Antigens, CD - immunology

Blotting, Southern

Burkitt Lymphoma - virology

Liver Transplantation - adverse effects

Humans

Lymphoproliferative Disorders - virology

Immunophenotyping

Male

Burkitt Lymphoma - etiology

Lymphoproliferative Disorders - pathology

Burkitt Lymphoma - pathology

Epstein-Barr Virus Infections - etiology

Biopsy

Fatal Outcome

Adult

Child

Immunoglobulin Heavy Chains - immunology

Lymphoproliferative Disorders - etiology

Details

Title: Subtitle: Burkitt s lymphoma variant of post-transplant lymphoproliferative disease (PTLD)
Creators: Melissa A Pasquale - Department of Pathology, University of Miami, Miami 33136, USA
Debbie Weppler
Jon Smith
Michael Icardi
Alexandra Amador
Monica Gonzalez - University of Miami
Tomoaki Kato
Andreas Tzakis
Phillip Ruiz
Resource Type: Journal article
Publication Details: Pathology oncology research, Vol.8(2), pp.105-108
DOI: 10.1007/BF03033718
PMID: 12172573
NLM abbreviation: Pathol Oncol Res
ISSN: 1219-4956
eISSN: 1532-2807
Publisher: Netherlands
Language: English
Date published: 2002
Academic Unit: Pathology
Record Identifier: 9984047640602771

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