Journal article
Bystander CD4 T cells do not mediate demyelination in mice infected with a neurotropic coronavirus
Journal of Neuroimmunology, Vol.137(1-2), pp.42-50
2003
DOI: 10.1016/S0165-5728(03)00041-9
PMID: 12667646
Abstract
Demyelination following infection of mice with the neurotropic coronavirus mouse hepatitis virus strain JHM (MHV) is immune-mediated. It has been demonstrated that MHV-specific CD4 and CD8 T cells are capable of causing demyelination independent of the other T cell subset. Recent work has also demonstrated that activated bystander CD8 T cells mediate significant demyelination. The ability of bystander CD4 T cells to mediate demyelination was investigated using CD4 T cell transgenic mice. The results indicated that bystander CD4 T cells were unable to cause demyelination in MHV-infected mice, despite being recruited into the central nervous system (CNS) and irrespective of activation status. These results suggest that CD4 T cells must recognize antigen in the CNS in order to cause demyelination.
Details
- Title: Subtitle
- Bystander CD4 T cells do not mediate demyelination in mice infected with a neurotropic coronavirus
- Creators
- Jodie S Haring - Department of Microbiology, University of Iowa, Iowa City, IA 52242, USAStanley Perlman - Department of Microbiology, University of Iowa, Iowa City, IA 52242, USA
- Resource Type
- Journal article
- Publication Details
- Journal of Neuroimmunology, Vol.137(1-2), pp.42-50
- DOI
- 10.1016/S0165-5728(03)00041-9
- PMID
- 12667646
- NLM abbreviation
- J Neuroimmunol
- ISSN
- 0165-5728
- eISSN
- 1872-8421
- Publisher
- Elsevier B.V
- Language
- English
- Date published
- 2003
- Academic Unit
- Microbiology and Immunology; Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Infectious Disease (Pediatrics)
- Record Identifier
- 9983777468902771
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