Bystander CD8 T-Cell-Mediated Demyelination is Interferon-γ -Dependent in a Coronavirus Model of Multiple Sclerosis

Ajai A Dandekar; Daniela Anghelina; Stanley Perlman

doi:10.1016/S0002-9440(10)63126-4

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Bystander CD8 T-Cell-Mediated Demyelination is Interferon-γ -Dependent in a Coronavirus Model of Multiple Sclerosis

Journal article

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Bystander CD8 T-Cell-Mediated Demyelination is Interferon-γ -Dependent in a Coronavirus Model of Multiple Sclerosis

Ajai A Dandekar, Daniela Anghelina and Stanley Perlman

American Journal of Pathology, Vol.164(2), pp.363-369

2004

DOI: 10.1016/S0002-9440(10)63126-4

PMCID: PMC1602263

PMID: 14742242

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Abstract

Mice infected with the coronavirus mouse hepatitis virus, strain JHM (JHM) develop a disease that shares many histological characteristics with multiple sclerosis. We previously demonstrated that JHM-infected mice that only have CD8 T cells specific for an epitope not in the virus develop demyelination on specific activation of these cells. Herein we show that this process of bystander T-cell-mediated demyelination is interferon-gamma (IFN-gamma)-dependent. The absence of IFN-gamma abrogated demyelination but did not change T-cell infiltration or expression levels of inflammatory cytokines or chemokines in the spinal cord. These results are consistent with models in which IFN-gamma contributes to CD8 T-cell-mediated demyelination by activation of macrophages/microglia, the final effector cells in the disease process.

Details

Title: Subtitle: Bystander CD8 T-Cell-Mediated Demyelination is Interferon-γ -Dependent in a Coronavirus Model of Multiple Sclerosis
Creators: Ajai A Dandekar
Daniela Anghelina
Stanley Perlman
Resource Type: Journal article
Publication Details: American Journal of Pathology, Vol.164(2), pp.363-369
DOI: 10.1016/S0002-9440(10)63126-4
PMID: 14742242
PMCID: PMC1602263
NLM abbreviation: Am J Pathol
ISSN: 0002-9440
eISSN: 1525-2191
Grant note: DOI: 10.13039/100000002, name: National Institutes of Health, award: NS 40438, NS42981, RG2864-B-3; DOI: 10.13039/100000002, name: National Institutes of Health, award: NS 40438, NS42981, RG2864-B-3; DOI: 10.13039/100000890, name: National Multiple Sclerosis Society, award: NS 40438, NS42981, RG2864-B-3
Language: English
Date published: 2004
Academic Unit: Microbiology and Immunology; Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Infectious Disease (Pediatrics)
Record Identifier: 9983777355102771

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