Bystander CD8 T cell-mediated demyelination after viral infection of the central nervous system

Jodie S Haring; Lecia L Pewe; Stanley Perlman

doi:10.4049/jimmunol.169.3.1550

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Bystander CD8 T cell-mediated demyelination after viral infection of the central nervous system

Journal article

Peer reviewed

Bystander CD8 T cell-mediated demyelination after viral infection of the central nervous system

Jodie S Haring, Lecia L Pewe and Stanley Perlman

Journal of immunology (Baltimore, Md. : 1950), Vol.169(3), pp.1550-1555

08/01/2002

DOI: 10.4049/jimmunol.169.3.1550

PMID: 12133983

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Abstract

Multiple sclerosis, a chronic inflammatory disease of the CNS, is characterized by immune-mediated demyelination. Many patients have a remitting-relapsing course of disease with exacerbations often following unrelated microbial illnesses. The relationship between the two events remains obscure. One possibility is that T cells specific for the inciting microbial pathogen are able to effect demyelination at a site of ongoing inflammation within the CNS. This possibility was examined in mice infected with mouse hepatitis virus, a well-described model of virus-induced demyelination. Using transgenic TCR/recombination activation gene 2(-/-) mice with only non-mouse hepatitis virus-specific T cells, we show that CD8 T cells are able to cause demyelination in the absence of cognate Ag in the CNS, but only if specifically activated. These findings demonstrate a novel mechanism for immune-mediated neuropathology and show that activated CD8 T cells may serve as important mediators of bystander demyelination during times of infection, including in patients with multiple sclerosis.

Central Nervous System Viral Diseases - complications

Chemokines - biosynthesis

Lymphocyte Activation

Mice, Inbred C57BL

Bystander Effect

Demyelinating Autoimmune Diseases, CNS - immunology

Murine hepatitis virus

Animals

Coronavirus Infections - complications

Demyelinating Autoimmune Diseases, CNS - etiology

Mice

Multiple Sclerosis - etiology

CD8-Positive T-Lymphocytes - immunology

Homeodomain Proteins - physiology

Cytokines - biosynthesis

Details

Title: Subtitle: Bystander CD8 T cell-mediated demyelination after viral infection of the central nervous system
Creators: Jodie S Haring - Department of Microbiology, University of Iowa, Iowa City, IA 52242, USA
Lecia L Pewe
Stanley Perlman
Resource Type: Journal article
Publication Details: Journal of immunology (Baltimore, Md. : 1950), Vol.169(3), pp.1550-1555
DOI: 10.4049/jimmunol.169.3.1550
PMID: 12133983
NLM abbreviation: J Immunol
ISSN: 0022-1767
eISSN: 1550-6606
Publisher: United States
Grant note: NS 40438 / NINDS NIH HHS P32 AI 07533 / NIAID NIH HHS
Language: English
Date published: 08/01/2002
Academic Unit: Microbiology and Immunology; Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Infectious Disease (Pediatrics)
Record Identifier: 9983777475102771

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