Journal article
C-Reactive Protein Monitoring Predicts Neutropenic Fever Following Autologous Hematopoietic Stem Cell Transplantation for Multiple Myeloma
Curēus (Palo Alto, CA), Vol.10(7), pp.e2945-e2945
07/08/2018
DOI: 10.7759/cureus.2945
PMCID: PMC6128584
PMID: 30202676
Abstract
Background
Neutropenic fever (NF) is a known and common complication of autologous hematopoietic stem cell transplantation (ASCT). Early risk assessment may help direct treatment. We retrospectively analyzed the role of serial serum C-reactive protein (CRP) levels in predicting NF and assessed the clinical value of CRP within 14 days after transplantation.
Methods
One hundred twenty-one multiple myeloma (MM) patients received 170 first and/or second ASCT between January 2014 and March 2017. A Cox regression model was applied to assess the prognostic value of CRP as a time-dependent covariate at the onset of NF within 14 days post-transplant.
Results
Forty-seven of 170 patients developed NF. High CRP levels (4.0–43.2 mg/dL) were associated with a 5.45-fold increased risk of NF (P = 0.02). Patients had a nearly three-fold increased risk of NF after the second transplant (P < 0.01), but this was not associated with increased mortality. Those with NF had higher maximum values of CRP (P < 0.01) which tended to occur at or after the onset of NF.
Conclusion
CRP monitoring provides important information about the risk for NF immediately after first MM ASCT, and even more so after the second.
Details
- Title: Subtitle
- C-Reactive Protein Monitoring Predicts Neutropenic Fever Following Autologous Hematopoietic Stem Cell Transplantation for Multiple Myeloma
- Creators
- Vidya Kollu - Medical College of WisconsinSarah L Mott - University of IowaRafiullah Khan - University of IowaUmar Farooq - University of IowaYogesh Jethava - University of IowaInce Dilek - University of IowaGuido Tricot - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Curēus (Palo Alto, CA), Vol.10(7), pp.e2945-e2945
- DOI
- 10.7759/cureus.2945
- PMID
- 30202676
- PMCID
- PMC6128584
- NLM abbreviation
- Cureus
- ISSN
- 2168-8184
- eISSN
- 2168-8184
- Publisher
- Cureus
- Language
- English
- Date published
- 07/08/2018
- Academic Unit
- Infectious Diseases; Hematology, Oncology, and Blood & Marrow Transplantation; Internal Medicine
- Record Identifier
- 9984362747302771
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