Journal article
C-erbB-2 expression and codon 12 K-ras mutations both predict shortened survival for patients with pulmonary adenocarcinomas
The Journal of clinical investigation, Vol.93(2), pp.516-520
02/1994
DOI: 10.1172/JCI117001
PMCID: PMC293872
PMID: 7906694
Abstract
We evaluated the prognostic significance of p185c-erbB-2 expression and ras gene mutations in all patients diagnosed with a pulmonary adenocarcinoma between 1982 and 1985 at the University of Iowa. p185c-erbB-2 expression was detected in 15 cases (34%). A ras gene mutation was found in 16 cases (36%) and all were in codon-12 of K-ras. No N-ras mutations were identified. Both p185c-erbB-2 expression and a K-ras mutation were found only in codon-12 and present in six cases (14%). By univariate analysis p185c-erbB-2 expression was associated with shortened survival (P = 0.02) while the presence of a K-ras mutation was not (P = 0.16). Multivariate analysis by the Cox proportional hazards model, controlling for patient age and tumor stage, also continued to identify p185c-erbB-2 expression as an independent unfavorable prognostic factor (P = 0.01). In this model a K-ras mutation also approached significance as a poor prognostic indicator (P = 0.06). The impact of both p185c-erbB-2 expression and a K-ras mutation on survival was additive and highly significant (P = 0.004). This additive nature suggests that together these two markers identify a high-risk population of lung adenocarcinoma patients that may benefit from aggressive therapy.
Details
- Title: Subtitle
- C-erbB-2 expression and codon 12 K-ras mutations both predict shortened survival for patients with pulmonary adenocarcinomas
- Creators
- Jeffrey A Kern - Department of Internal Medicine, University of Iowa, Iowa City 52242Robbert J C Slebos - Department of Internal Medicine, University of Iowa, Iowa City 52242Bert Top - Department of Internal Medicine, University of Iowa, Iowa City 52242Sjoerd Rodenhuis - Department of Internal Medicine, University of Iowa, Iowa City 52242Donna Lager - Department of Internal Medicine, University of Iowa, Iowa City 52242Robert A Robinson - Department of Internal Medicine, University of Iowa, Iowa City 52242David Weiner - Department of Internal Medicine, University of Iowa, Iowa City 52242David A Schwartz - Department of Internal Medicine, University of Iowa, Iowa City 52242
- Resource Type
- Journal article
- Publication Details
- The Journal of clinical investigation, Vol.93(2), pp.516-520
- DOI
- 10.1172/JCI117001
- PMID
- 7906694
- PMCID
- PMC293872
- ISSN
- 0021-9738
- eISSN
- 1558-8238
- Language
- English
- Date published
- 02/1994
- Academic Unit
- Oral Pathology, Radiology and Medicine; Pathology
- Record Identifier
- 9984048000202771
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