Journal article
C-reactive protein as a predictor of cardiovascular events in elderly patients with chronic kidney disease
Journal of nephrology, Vol.25(5), pp.719-725
2012
DOI: 10.5301/jn.5000047
PMCID: PMC3704176
PMID: 22038335
Abstract
Background: Few studies have evaluated the relationship between high-sensitivity C-reactive protein (hs-CRP) and vascular events in the elderly with chronic kidney disease (CKD).
Methods: The association of hs-CRP with vascular events was examined according to CKD status in 3,166 participants of the Intervention Project on Cerebrovascular Diseases and Dementia in the Community of Ebersberg, Bavaria (INVADE study). CKD was defined as a creatinine clearance <60 ml/min estimated by the Cockcroft-Gault formula. hs-CRP was used as a binary variable > or <2.1 mg/L (median value). Vascular events were defined as a composite of myocardial infarction, stroke and vascular death.
Results: After 4 years of follow-up, 204 participants (6.4%) experienced a major cardiovascular event. High hs-CRP levels and CKD at baseline were associated with a greater risk of vascular events. Compared with patients with low hs-CRP and non-CKD, the adjusted hazard ratio (95% confidence interval) for vascular events was 1.42 (1.11-2.21) for low hs-CRP and CKD, 1.57 (1.21-2.34) for high hs-CRP and non-CKD and 1.93 (1.45-2.89) for high hs-CRP and CKD.
Conclusions: These results suggest that high hs-CRP levels provide prognostic information in patients with CKD.
Details
- Title: Subtitle
- C-reactive protein as a predictor of cardiovascular events in elderly patients with chronic kidney disease
- Creators
- Diana Jalal - University of Colorado at Denver Health Sciences Center, Denver, CO, United StatesMichel Chonchol - University of Colorado at Denver Health Sciences Center, Denver, CO, United StatesThorleif Etgen - Psychiatry and Psychotherapy, Technical University of Munich, Munich, GermanyDirk Sander - Neurology, Technical University of Munich, Munich, Germany
- Resource Type
- Journal article
- Publication Details
- Journal of nephrology, Vol.25(5), pp.719-725
- DOI
- 10.5301/jn.5000047
- PMID
- 22038335
- PMCID
- PMC3704176
- NLM abbreviation
- J Nephrol
- ISSN
- 1121-8428
- eISSN
- 1724-6059
- Grant note
- K23 DK088833 || DK / National Institute of Diabetes and Digestive and Kidney Diseases : NIDDK R01 DK081473 || DK / National Institute of Diabetes and Digestive and Kidney Diseases : NIDDK
- Language
- English
- Date published
- 2012
- Academic Unit
- Nephrology; Internal Medicine
- Record Identifier
- 9984094778702771
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