Journal article
C58 and AKR mice of all ages develop motor neuron disease after lactate dehydrogenase-elevating virus infection but only if antiviral immune responses are blocked by chemical or genetic means or as a result of old age
Journal of neurovirology, Vol.1(3-4), pp.244-252
1995
DOI: 10.3109/13550289509114020
PMID: 9222362
Abstract
Age-dependent poliomyelitis is a paralytic disease of C58 and AKR mice caused by cytocidal infection of anterior horn neurons with neuropathogenic strains of lactate dehydrogenase-elevating virus (LDV). The motor neurons are rendered LDV-permissive via an unknown mechanism through the expression of ecotropic murine leukemia virus (MuLV) in central nervous system (CNS) glial cells. Only old mice develop paralytic disease after LDV infection, but mice 5-6 months old or older can be rendered susceptible by suppression of anti-LDV immune responses by a single treatment with cyclophosphamide or X-irradiation before LDV infection. Younger mice appeared to be resistant in spite of this immunosuppresive treatment. The present results confirm that mice as young as 1 month of age possess CNS cells expressing ecotropic MuLV and show that these mice are susceptible to paralytic LDV infection provided their anti-LDV immune responses are blocked for an extended period of time by repeated cyclophosphamide treatments or by a genetic defect. Furthermore, old mice become naturally susceptible to paralytic LDV infection because of an impaired ability to mount a motor neuron protective anti-LDV immune response.
Details
- Title: Subtitle
- C58 and AKR mice of all ages develop motor neuron disease after lactate dehydrogenase-elevating virus infection but only if antiviral immune responses are blocked by chemical or genetic means or as a result of old age
- Creators
- Grant W Anderson - 1Department of Microbiology, University of Minnesota Medical School, 1460 Mayo Memorial Building, 420 Delaware Street SE, Minneapolis, Minnesota, 55455 - 0312, USAChen Even - 1Department of Microbiology, University of Minnesota Medical School, 1460 Mayo Memorial Building, 420 Delaware Street SE, Minneapolis, Minnesota, 55455 - 0312, USARaymond RR Rowland - 1Department of Microbiology, University of Minnesota Medical School, 1460 Mayo Memorial Building, 420 Delaware Street SE, Minneapolis, Minnesota, 55455 - 0312, USAGene A Palmer - 1Department of Microbiology, University of Minnesota Medical School, 1460 Mayo Memorial Building, 420 Delaware Street SE, Minneapolis, Minnesota, 55455 - 0312, USAJohn T Harty - 1Department of Microbiology, University of Minnesota Medical School, 1460 Mayo Memorial Building, 420 Delaware Street SE, Minneapolis, Minnesota, 55455 - 0312, USAPeter GW Plagemann - 1Department of Microbiology, University of Minnesota Medical School, 1460 Mayo Memorial Building, 420 Delaware Street SE, Minneapolis, Minnesota, 55455 - 0312, USA
- Resource Type
- Journal article
- Publication Details
- Journal of neurovirology, Vol.1(3-4), pp.244-252
- Publisher
- Informa UK Ltd
- DOI
- 10.3109/13550289509114020
- PMID
- 9222362
- ISSN
- 1355-0284
- eISSN
- 1538-2443
- Language
- English
- Date published
- 1995
- Academic Unit
- Pathology
- Record Identifier
- 9984046905102771
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