Journal article
CANCER MORTALITY AND LIPID AND LIPOPROTEIN LEVELS
American journal of epidemiology, Vol.131(3), pp.468-482
03/1990
DOI: 10.1093/oxfordjournals.aje.a115521
Abstract
The associations of serum lipid and lipoprotein levels with the risk of cancer mortality were assessed in 2,753 men and 2,476 women aged 40–79 years at baseline (1972–1976) who participated in the Lipid Research Clinics Program Mortality Follow-up Study through 1984. Seventy-nine cancer deaths occurred in men and 65 occurred in women during an average follow-up time of 8.4years. Total cholesterol and low-density lipoprotein (LDL) cholesterol were significantly inversely associated with overall cancer mortality in men, but no relation was observed in women. Neither high-density lipoprotein (HDL) cholesterol nor tri-gtycerides were significantly related to total cancer mortality in either sex, although in women, HDL cholesterol was positively associated with risk of death from gynecologic cancers. Compared with men with higher cholesterol levels, the relative risk of death from colon cancer, adjusted for age, body mass, cigarette smoking, and alcohol consumption, was 5.20 (95 percent confidence interval (Cl) 1.61–16.8) in men with total cholesterol levels ≤87 mg/dl and 4.79 (95 percent Cl 1.37–16.8) in those with LDL cholesterol levels ≤119 mg/dl. Death from smoking-related cancers was inversely related to baseline total cholesterol but not to LDL cholesterol. The absence of an association with HDL cholesterol, which has been shown to be lower in persons with clinically manifest malignancy, and evidence from survival curves suggest that the inverse relation in men is not due to preexisting disease.
Details
- Title: Subtitle
- CANCER MORTALITY AND LIPID AND LIPOPROTEIN LEVELS
- Creators
- LINDA D. Cowan - University of Oklahoma Health Sciences CenterDIANNE L. O'CONNELL - University of Newcastle AustraliaMICHAEL H. Criqui - Department of Community and Family Medicine, School of Medicine, University of California at San DiegoLa Jolla, CAELIZABETH BARRETT-CONNOR - Department of Community and Family Medicine, School of Medicine, University of California at San DiegoLa Jolla, CATRUDY L. Bush - Johns Hopkins UniversityROBERT B. Wallace - University of Iowa
- Resource Type
- Journal article
- Publication Details
- American journal of epidemiology, Vol.131(3), pp.468-482
- DOI
- 10.1093/oxfordjournals.aje.a115521
- ISSN
- 0002-9262
- eISSN
- 1476-6256
- Publisher
- Oxford University Press
- Language
- English
- Date published
- 03/1990
- Academic Unit
- Epidemiology; Injury Prevention Research Center; Internal Medicine
- Record Identifier
- 9984364413102771
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