CCK-A receptor induction and P38MAPK and NF-κB activation in acute pancreatitis

Isaac Samuel; Smita Zaheer; Jeffrey J. Nelson; Mark A. Yorek; Asgar Zaheer

doi:10.1159/000077067

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CCK-A receptor induction and P38MAPK and NF-κB activation in acute pancreatitis

Journal article

Peer reviewed

CCK-A receptor induction and P38MAPK and NF-κB activation in acute pancreatitis

Isaac Samuel, Smita Zaheer, Jeffrey J. Nelson, Mark A. Yorek and Asgar Zaheer

Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.], Vol.4(1), pp.49-56

2004

DOI: 10.1159/000077067

PMID: 14988658

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Abstract

Bile-pancreatic duct ligation in rats excludes bile-pancreatic juice from the gut and induces acute pancreatitis. Bile-pancreatic juice exclusion from the gut results in increased plasma cholecystokinin (CCK) levels. CCK-A receptor-mediated exocrine pancreatic hyperstimulation is implicated in disease pathogenesis. In the present study, we show for the first time a progressive rise in CCK-A receptor protein expression in ligation-induced acute pancreatitis in rats. As CCK-A receptor induction could amplify CCK-mediated acinar hyperstimulation and exacerbate acinar cell stress with activation of the p38MAPK stress kinase pathway, we studied CCK-A receptor protein expression and p38MAPK activation in duct ligation-induced acute pancreatitis in rats. Compared to sham-operated controls, acute pancreatitis induced by bile-pancreatic duct ligation associates with a temporal increase in pancreatic CCK-A receptor protein expression, p38MAPK expression and activation, and NF-κB activation. These findings may have significance in the mechanism of disease pathogenesis in this experimental model.

Acinar cell

Acute pancreatitis

Cholecystokinin

Cholecystokinin-A receptor

Donor rat model

NF-κB

p38 MAP kinase

Signal transduction

Stress-activated protein kinase

Details

Title: Subtitle: CCK-A receptor induction and P38MAPK and NF-κB activation in acute pancreatitis
Creators: Isaac Samuel - Veterans Health Administration
Smita Zaheer - Veterans Health Administration
Jeffrey J. Nelson - Veterans Health Administration
Mark A. Yorek - Veterans Health Administration
Asgar Zaheer - Veterans Health Administration
Resource Type: Journal article
Publication Details: Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.], Vol.4(1), pp.49-56
Publisher: Elsevier B.V
DOI: 10.1159/000077067
PMID: 14988658
ISSN: 1424-3903
eISSN: 1424-3911
Language: English
Date published: 2004
Academic Unit: Neurology; Surgery; Fraternal Order of Eagles Diabetes Research Center; Endocrinology and Metabolism; Internal Medicine
Record Identifier: 9984322795802771

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