Journal article
CD10 Is Inversely Associated with Nuclear Factor-Kappa B and Predicts Biochemical Recurrence after Radical Prostatectomy
Urologia internationalis, Vol.88(2), pp.158-164
01/01/2012
DOI: 10.1159/000335299
PMID: 22286396
Abstract
Introduction: The cell surface endopeptidase CD10 (neutral endopeptidase) and nuclear factor-kappa B (NF-kappa B) have been independently associated with prostate cancer (PC) progression. We investigated the correlations between these two factors and their prognostic relevance in terms of biochemical (prostate-specific antigen, PSA) relapse after radical prostatectomy (RP) for localized PC. Patients and Methods: The immunohistochemical expression of CD10 and NF-kappa B in samples from 70 patients who underwent RP for localized PC was correlated with the preoperative PSA level, Gleason score, pathological stage and time to PSA failure. Results: CD10 expression was inversely associated with NF-kappa B expression (p < 0.001), stage (p = 0.03) and grade (p = 0.003), whereas NF-kappa B was directly related with stage (p = 0.006) and grade (p = 0.002). The median time to PSA failure was 56 months. CD10 and NF-kappa B were directly (p < 0.001) and inversely (p < 0.001) correlated with biochemical recurrence-free survival, respectively. CD10 expression (p = 0.022) and stage (p = 0.018) were independently associated with time to biochemical recurrence. Conclusion: Low CD10 expression is an adverse prognostic factor for biochemical relapse after RP in localized PC, which is also associated with high NF-kappa B expression. Decreased CD10 expression which would lead to increased neuropeptide signaling and NF-kappa B activity may be present in a subset of early PCs. Copyright (C) 2012 S. Karger AG, Basel
Details
- Title: Subtitle
- CD10 Is Inversely Associated with Nuclear Factor-Kappa B and Predicts Biochemical Recurrence after Radical Prostatectomy
- Creators
- Ioannis A. Voutsadakis - University of ThessalyPanagiotis J. Vlachostergios - University of ThessalyDanai D. Daliani - University of ThessalyFoteini Karasavvidou - University of ThessalyGrigorios Kakkas - University of ThessalyGeorge Moutzouris - University of ThessalyMichael D. Melekos - University of ThessalyChristos N. Papandreou - University of Thessaly
- Resource Type
- Journal article
- Publication Details
- Urologia internationalis, Vol.88(2), pp.158-164
- Publisher
- Karger
- DOI
- 10.1159/000335299
- PMID
- 22286396
- ISSN
- 0042-1138
- eISSN
- 1423-0399
- Number of pages
- 7
- Language
- English
- Date published
- 01/01/2012
- Academic Unit
- Internal Medicine
- Record Identifier
- 9984806512302771
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