CD1b restricts the response of human CD4-8- T lymphocytes to a microbial antigen

Steven Porcelli; Craig T Morita; Michael B Brenner

doi:10.1038/360593a0

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CD1b restricts the response of human CD4-8- T lymphocytes to a microbial antigen

Journal article

Peer reviewed

CD1b restricts the response of human CD4-8- T lymphocytes to a microbial antigen

Steven Porcelli, Craig T Morita and Michael B Brenner

Nature (London), Vol.360(6404), pp.593-597

12/10/1992

DOI: 10.1038/360593a0

PMID: 1281285

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Abstract

Molecules encoded by the human CD1 locus on chromosome 1 (ref. 33) are recognized by selected CD4-8- T-cell clones expressing either alpha beta or gamma delta T-cell antigen receptors. The known structural resemblance of CD1 molecules to antigen-presenting molecules encoded by major histocompatibility complex (MHC) genes on human chromosome 6 (refs 3, 4, 34, 35), suggested that CD1 may represent a family of antigen-presenting molecules separate from those encoded in the MHC. Here we report that the proliferative and cytotoxic responses of human CD4-8- alpha beta TCR+ T cells specific for Mycobacterium tuberculosis can be restricted by CD1b, one of the four identified protein products of the CD1 locus. The responses of these T cells to M. tuberculosis seemed not to involve MHC encoded molecules, but were absolutely dependent on the expression of CD1b by the antigen-presenting cell and involved an antigen processing requirement similar to that seen in MHC class II-restricted antigen presentation. These results provide, to our knowledge, the first direct evidence for the proposed antigen-presenting function of CD1 molecules and suggest that the CD1 family plays a role in cell-mediated immunity to microbial pathogens.

Transfection

Antigens, CD - immunology

Chloroquine

Humans

Antigens, Bacterial - immunology

Mycobacterium tuberculosis - immunology

Antigens, CD1

Granulocyte-Macrophage Colony-Stimulating Factor - pharmacology

Antigen-Presenting Cells - immunology

Antigens, CD - genetics

CD8 Antigens - analysis

Interleukin-4 - pharmacology

B-Lymphocytes - immunology

Fixatives

CD4 Antigens - analysis

T-Lymphocytes - immunology

Glutaral - pharmacology

Details

Title: Subtitle: CD1b restricts the response of human CD4-8- T lymphocytes to a microbial antigen
Creators: Steven Porcelli - Department of Rheumatology/Immunology, Brigham and Women's Hospital, Boston, Massachusetts
Craig T Morita
Michael B Brenner
Resource Type: Journal article
Publication Details: Nature (London), Vol.360(6404), pp.593-597
DOI: 10.1038/360593a0
PMID: 1281285
NLM abbreviation: Nature
ISSN: 0028-0836
eISSN: 1476-4687
Language: English
Date published: 12/10/1992
Academic Unit: Immunology; Internal Medicine
Record Identifier: 9984094642602771

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