Journal article
CD28 −CD57 + T cells predominate in CD8 responses to glatiramer acetate
Journal of neuroimmunology, Vol.178(1), pp.117-129
2006
DOI: 10.1016/j.jneuroim.2006.06.001
PMID: 16837065
Abstract
Human T cells adopt a CD28
−CD57
+ phenotype in chronic viral infections and this has been hypothesized to result from continuous stimulation, however this phenotype may be due to direct viral effects on T cells. Employing MS patients before and after chronic
in vivo administration of the antigen glatiramer acetate (GA) we examine this hypothesis. Pre-treatment glatiramer acetate-specific CD8 T cells were CD57
−Perforin
−. This changed to a predominantly CD28
−CD57
+Perforin
+ response after administration of this drug. This phenotype was only observed after chronic stimulation and not in a recall response to mumps. The relevance to GA's mechanism of action is discussed.
Details
- Title: Subtitle
- CD28 −CD57 + T cells predominate in CD8 responses to glatiramer acetate
- Creators
- Robert B Ratts - Department of Neurology, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390-9036, USAAmy E Lovett-Racke - Department of Neurology, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390-9036, USAJudy Choy - Department of Neurology, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390-9036, USASara C Northrop - Department of Neurology, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390-9036, USARehana Z Hussain - Department of Neurology, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390-9036, USANitin J Karandikar - Department of Neurology, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390-9036, USAMichael K Racke - Department of Neurology, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390-9036, USA
- Resource Type
- Journal article
- Publication Details
- Journal of neuroimmunology, Vol.178(1), pp.117-129
- Publisher
- Elsevier B.V
- DOI
- 10.1016/j.jneuroim.2006.06.001
- PMID
- 16837065
- ISSN
- 0165-5728
- eISSN
- 1872-8421
- Language
- English
- Date published
- 2006
- Academic Unit
- Pathology
- Record Identifier
- 9984047606602771
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