Journal article
CD33 Alzheimer’s disease locus: Altered monocyte function and amyloid biology
Nature neuroscience, Vol.16(7), pp.848-850
07/2013
DOI: 10.1038/nn.3435
PMCID: PMC3703870
PMID: 23708142
Abstract
In our functional dissection of the
CD33
Alzheimer’s disease susceptibility locus, we find that the rs3865444
C
risk allele is associated with greater cell surface expression of CD33 in monocytes (
t
50
= 10.06, pjoint=1.3×10–13) of young and older individuals. It is also associated with (1) diminished internalization of Aβ42) (2) accumulation of neuritic amyloid pathology and fibrillar amyloid on
in vivo
imaging and (3), increased numbers of activated human microglia.
Details
- Title: Subtitle
- CD33 Alzheimer’s disease locus: Altered monocyte function and amyloid biology
- Creators
- Elizabeth M Bradshaw - Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USALori B Chibnik - Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USABrendan T Keenan - Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USALinda Ottoboni - Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USATowfique Raj - Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USAAnna Tang - Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USALaura L Rosenkrantz - Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USASelina Imboywa - Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USAMichelle Lee - Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USAAlina Von Korff - Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USAAlzheimer Disease Neuroimaging InitiativeMartha C Morris - Rush Alzheimer’s Disease Center, Rush University Medical Center, 600 S Paulina St., Chicago, IL 60612Denis A Evans - Rush Institute for Healthy Aging, Rush University Medical Center,1645 W. Jackson Blvd., Chicago 60612Keith Johnson - Harvard Medical School, Boston, MA 02115Reisa A Sperling - Harvard Medical School, Boston, MA 02115Julie A Schneider - Rush Alzheimer’s Disease Center, Rush University Medical Center, 600 S Paulina St., Chicago, IL 60612David A Bennett - Rush Alzheimer’s Disease Center, Rush University Medical Center, 600 S Paulina St., Chicago, IL 60612Philip L De Jager - Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
- Contributors
- Laura L Boles-Ponto (Contributor) - University of Iowa, Radiology
- Resource Type
- Journal article
- Publication Details
- Nature neuroscience, Vol.16(7), pp.848-850
- DOI
- 10.1038/nn.3435
- PMID
- 23708142
- PMCID
- PMC3703870
- ISSN
- 1097-6256
- eISSN
- 1546-1726
- Language
- English
- Date published
- 07/2013
- Academic Unit
- Radiology; Pharmaceutical Sciences and Experimental Therapeutics
- Record Identifier
- 9984051774102771
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