Journal article
CD4 T Cell-Dependent and -Independent Roles for IFN-γ in Blood-Stage Malaria
The Journal of immunology (1950), Vol.210(9), pp.1305-1313
05/01/2023
DOI: 10.4049/jimmunol.2200899
PMCID: PMC10121907
PMID: 36939394
Abstract
Production of IFN-γ by CD4 T cells is widely theorized to control Plasmodium parasite burden during blood-stage malaria. Surprisingly, the specific and crucial mechanisms through which this highly pleiotropic cytokine acts to confer protection against malarial disease remain largely untested in vivo. Here we used a CD4 T cell-restricted Cre-Lox IFN-γ excision mouse model to test whether and how CD4 T cell-derived IFN-γ controls blood-stage malaria. Although complete absence of IFN-γ compromised control of the acute and the chronic, recrudescent blood-stage infections with P. c. chabaudi, we identified a specific, albeit modest, role for CD4 T cell-derived IFN-γ in limiting parasite burden only during the chronic stages of P. c. chabaudi malaria. CD4 T cell IFN-γ promoted IgG Ab class switching to the IgG2c isotype during P. c. chabaudi malaria in C57BL/6 mice. Unexpectedly, our data do not support gross defects in phagocytic activity in IFN-γ-deficient hosts infected with blood-stage malaria. Together, our data confirm CD4 T cell-dependent roles for IFN-γ but suggest CD4 T cell-independent roles for IFN-γ in immune responses to blood-stage malaria.
Details
- Title: Subtitle
- CD4 T Cell-Dependent and -Independent Roles for IFN-γ in Blood-Stage Malaria
- Creators
- Lisa L DrewryLecia L PeweLisa S HancoxStephanie Van de WallJohn T Harty
- Resource Type
- Journal article
- Publication Details
- The Journal of immunology (1950), Vol.210(9), pp.1305-1313
- DOI
- 10.4049/jimmunol.2200899
- PMID
- 36939394
- PMCID
- PMC10121907
- NLM abbreviation
- J Immunol
- ISSN
- 0022-1767
- eISSN
- 1550-6606
- Grant note
- DOI: 10.13039/100000060, name: HHS | NIH | National Institute of Allergy and Infectious Diseases, award: AI167847; DOI: 10.13039/100000060, name: HHS | NIH | National Institute of Allergy and Infectious Diseases, award: AI42767; DOI: 10.13039/100000060, name: HHS | NIH | National Institute of Allergy and Infectious Diseases, award: AI100527; DOI: 10.13039/100000060, name: HHS | NIH | National Institute of Allergy and Infectious Diseases, award: AI114543; DOI: 10.13039/100000060, name: HHS | NIH | National Institute of Allergy and Infectious Diseases, award: T32AI; DOI: 10.13039/100000060, name: HHS | NIH | National Institute of Allergy and Infectious Diseases, award: F32AI167088
- Language
- English
- Electronic publication date
- 03/20/2023
- Date published
- 05/01/2023
- Academic Unit
- Pathology
- Record Identifier
- 9984380464502771
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