CD4 T-cell-mediated demyelination is increased in the absence of gamma interferon in mice infected with mouse hepatitis virus

Lecia Pewe; Jodie Haring; Stanley Perlman

doi:10.1128/JVI.76.14.7329-7333.2002

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CD4 T-cell-mediated demyelination is increased in the absence of gamma interferon in mice infected with mouse hepatitis virus

Journal article

Open access

Peer reviewed

CD4 T-cell-mediated demyelination is increased in the absence of gamma interferon in mice infected with mouse hepatitis virus

Lecia Pewe, Jodie Haring and Stanley Perlman

Journal of virology, Vol.76(14), pp.7329-7333

07/2002

DOI: 10.1128/JVI.76.14.7329-7333.2002

PMCID: PMC136326

PMID: 12072531

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Abstract

Mice infected with the murine coronavirus, mouse hepatitis virus, strain JHM (MHV) develop an immune-mediated demyelinating encephalomyelitis. Adoptive transfer of MHV-immune splenocytes depleted of either CD4 or CD8 T cells to infected mice deficient in recombination activation gene 1 resulted in demyelination. We showed previously that the process of CD8 T-cell-mediated demyelination was strongly dependent on the expression of gamma interferon (IFN-gamma) by donor cells. In this report, we show, in contrast, that demyelination and lymphocyte infiltration were increased in recipients of IFN-gamma(-/-) CD4 T cells when compared to levels in mice receiving C57BL/6 CD4 T cells.

Central Nervous System Viral Diseases - physiopathology

Demyelinating Diseases - physiopathology

Mice, Inbred C57BL

Coronavirus Infections - physiopathology

Interferon-gamma - physiology

Adoptive Transfer

Murine hepatitis virus - pathogenicity

Coronavirus Infections - immunology

Genes, RAG-1

CD4-Positive T-Lymphocytes - immunology

Animals

CD4-Positive T-Lymphocytes - transplantation

Demyelinating Diseases - immunology

Mice

Interferon-gamma - genetics

Central Nervous System Viral Diseases - immunology

Details

Title: Subtitle: CD4 T-cell-mediated demyelination is increased in the absence of gamma interferon in mice infected with mouse hepatitis virus
Creators: Lecia Pewe - Department of Pediatrics, University of Iowa, Iowa City, Iowa 52242, USA
Jodie Haring
Stanley Perlman
Resource Type: Journal article
Publication Details: Journal of virology, Vol.76(14), pp.7329-7333
DOI: 10.1128/JVI.76.14.7329-7333.2002
PMID: 12072531
PMCID: PMC136326
NLM abbreviation: J Virol
ISSN: 0022-538X
eISSN: 1098-5514
Publisher: United States
Grant note: NS40438-01 / NINDS NIH HHS R01 NS040438 / NINDS NIH HHS
Language: English
Date published: 07/2002
Academic Unit: Microbiology and Immunology; Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Infectious Disease (Pediatrics)
Record Identifier: 9983777472802771

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