Journal article
CD4(+) regulatory T cells in a cynomolgus macaque model of Mycobacterium tuberculosis infection
The Journal of infectious diseases, Vol.202(4), pp.533-541
08/15/2010
DOI: 10.1086/654896
PMCID: PMC3683560
PMID: 20617900
Abstract
Mycobacterium tuberculosis infection in humans results in either latent infection or active tuberculosis. We sought to determine whether a higher frequency of regulatory T (T(reg)) cells predispose an individual toward active disease or whether T(reg) cells develop in response to active disease.
In cynomolgus macaques infected with a low dose of M. tuberculosis, approximately 50% develop primary tuberculosis, and approximately 50% become latently infected. Forty-one animals were monitored for 6-8 months to assess the correlation of the frequency of Foxp3(+) cells in peripheral blood and airways with the outcome of infection.
In all animals, the frequency of T(reg) cells (CD4(+)Foxp3(+)) in peripheral blood rapidly decreased and simultaneously increased in the airways. Latently infected monkeys had a significantly higher frequency of T(reg) cells in peripheral blood before infection and during early infection, compared with monkeys that developed active disease. Monkeys with active disease experienced increased frequencies of T(reg) cells among peripheral blood mononuclear cells as they developed disease.
Our data suggest that increased frequencies of T(reg) cells in active disease occur in response to increased inflammation rather than act as a causative factor in progression to active disease.
Details
- Title: Subtitle
- CD4(+) regulatory T cells in a cynomolgus macaque model of Mycobacterium tuberculosis infection
- Creators
- Angela M Green - University of PittsburghJoshua T Mattila - University of PittsburghCarolyn L Bigbee - University of PittsburghKale S Bongers - University of PittsburghP Ling Lin - Children's Hospital of PittsburghJoanne L Flynn - University of Pittsburgh
- Resource Type
- Journal article
- Publication Details
- The Journal of infectious diseases, Vol.202(4), pp.533-541
- DOI
- 10.1086/654896
- PMID
- 20617900
- PMCID
- PMC3683560
- ISSN
- 0022-1899
- eISSN
- 1537-6613
- Grant note
- R01-AI50732 / NIAID NIH HHS T32 AI060525-03 / NIAID NIH HHS R01 AI050732-08 / NIAID NIH HHS R01-075845 / PHS HHS T32 AI060525 / NIAID NIH HHS R01 AI050732 / NIAID NIH HHS R01 HL075845 / NHLBI NIH HHS R01 AI050732-07 / NIAID NIH HHS T32 AI060525-02 / NIAID NIH HHS R01 AI050732-06A2 / NIAID NIH HHS T32-AI060525 / NIAID NIH HHS R01 HL075845-05 / NHLBI NIH HHS
- Language
- English
- Date published
- 08/15/2010
- Academic Unit
- Internal Medicine
- Record Identifier
- 9984696757002771
Metrics
7 Record Views